Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | PRNP | P04156 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazolinone SCHEMBL10418 | 0.98 | PARP1 (0.48) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL8201415 | 0.96 | PARP1 (0.47) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL7746268 | 0.96 | PARP1 (0.47) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL7744396 | 0.94 | PARP1 (0.46) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL27387957 | 0.87 | PBRM1 (0.42) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL27370560 | 0.87 | PBRM1 (0.46) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL5266556 | 0.86 | ALDH1A1 (0.42) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL27369780 | 0.84 | SMN1; SMN2 (0.39) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL28177707 | 0.78 | CA12 (0.58) | PARP1PDPK1CA12CA9CDK4 | |
| SCHEMBL29258736 | 0.75 | PDE3B (0.44) | PARP1SMN1; SMN2PDPK1CA12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189469-B | 2-amino-3, 4-dihydroquinazoline derivatives and their use as cathepsin D inhibitors | 默克专利股份公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-106083741-A | 2 sulfur are for quinazolinedione derivatives | 南京中医药大学 | 2016-11-09 | — | — | CN | disclosed |