Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PRNP | P04156 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazolinone SCHEMBL10418 | 0.96 | PARP1 (0.48) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL8201415 | 0.94 | PARP1 (0.47) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL28241793 | 0.94 | PARP1 (0.47) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL7746268 | 0.94 | PARP1 (0.47) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL27387957 | 0.85 | PBRM1 (0.42) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL27370560 | 0.85 | PBRM1 (0.46) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL5266556 | 0.84 | ALDH1A1 (0.42) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL27369780 | 0.83 | SMN1; SMN2 (0.39) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| Quinazolinone SCHEMBL28177707 | 0.77 | CA12 (0.58) | PARP1PDPK1CA12CA9CDK4 | |
| SCHEMBL8700858 | 0.73 | PARP1 (0.54) | PARP1SMN1; SMN2CA12CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6429311-B2 | CHEMICAL INTERMEDIATE FOR HYPOTENSIVE AGENTS, BACTERICIDES, FUNGICIDES, ANTIPYRETICS AND ANTIDEPRESSANTS | SEPRACOR INC. | 2002-08-06 | — | — | US | disclosed |
| US-20010018518-A1 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof | GAO YUN (US) | 2001-08-30 | — | — | US | disclosed |
| US-6184377-B1 | ANTIPYRETIC, HYPOTENSIVE, ANTIBACTERIAL, ANTIFUNGAL OR CENTRAL NERVOUS SYSTEM (CNS) ACTIVITY, AS WELL AS THE ABILITY TO INHIBIT ENZYMES | SEPRACOR INC. | 2001-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010018518-A1 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof | NQO2, ASNS, AAAS | PARP1 2912/4885SMN1; SMN2 3617/4885PDPK1 3692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.