SCHEMBL27375786

SCHEMBL27375786

COc1ccc(OC(=O)CNC(=N)N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
KMT2A Q03164 2/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPT P10636 1/20 0.47
HTT P42858 1/20 0.47
HSD17B10 Q99714 1/20 0.47
GAA P10253 4/20 0.46
CYP2C19 P33261 2/20 0.46
CYP1A2 P05177 1/20 0.46
CA1 P00915 3/20 0.45
CA2 P00918 3/20 0.45
TDP1 Q9NUW8 2/20 0.44
PARP10 Q53GL7 2/20 0.44
PRSS1 P07477 1/20 0.44
PRSS2 P07478 1/20 0.44
PRSS3 P35030 1/20 0.44
PARP1 P09874 1/20 0.44
PARP2 Q9UGN5 1/20 0.44
PARP4 Q9UKK3 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27257811 0.85 MAPT (0.41) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL27357774 0.85 MAPT (0.41) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL27461665 0.85 KMT2A (0.45) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL27652407 0.85 LMNA (0.48) LMNAKMT2AGAAPRSS1PRSS2
SCHEMBL27639181 0.84 KMT2A (0.48) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL27539482 0.84 ALDH1A1 (0.50) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL28753675 0.84 SMN1; SMN2 (0.47) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL27532791 0.84 KMT2A (0.43) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL28214445 0.84 KMT2A (0.40) LMNAKMT2AALDH1A1MAPTHTT
SCHEMBL27502925 0.84 MGLL (0.42) LMNAKMT2AALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101146871-A Surface modified nanoparticle and method of preparing same 3M INNOVATIVE PROPERTIES CO (US) 2008-03-19 CN claimed
CN-101146869-A Methods of preparing polymer nanocomposite having surface modified nanoparticles 3M INNOVATIVE PROPERTIES CO (US) 2008-03-19 CN claimed
CN-101146870-A Polymer nanocomposite having surface modified nanoparticles and methods of preparing same 3M INNOVATIVE PROPERTIES CO (US) 2008-03-19 CN claimed
CN-1060770-A The sweetness inhibitor that contains substantially tasteless is as bitter inhibitor or contain the absorbed thing of the bitter inhibitor of substantially tasteless as sweetness inhibitor BIORESEARCH INC (US) 1992-05-06 CN claimed
CN-101984755-B Continuous process for producing amides of lower aliphatic carboxylic acids CLARIANT FINANCE BVI LTD 2014-11-12 CN disclosed
CN-101784520-B Novel malonic acid sulfonamide derivative and pharmaceutical use thereof MITSUBISHI TANABE PHARMA CORP 2014-07-02 CN disclosed
CN-103342682-A Intermediate for preparing pyrimidine derivatives ASTRAZENECA AB 2013-10-09 CN disclosed
CN-103193840-A Macrolide derivative TAISHO PHARMACEUTICAL CO LTD 2013-07-10 CN disclosed
CN-101925584-B Pyrimidine Derivatives for the Treatment of Asthma, COPD, Allergic Rhinitis, Allergic Conjunctivitis, Atopic Dermatitis, Cancer, Hepatitis B, Hepatitis C, HIV, HPV, Bacterial Infections and Skin Diseases ASTRAZENECA AB 2013-04-17 CN disclosed
CN-101454334-B Macrolide derivatives TAISHO PHARMACEUTICAL CO LTD 2013-04-10 CN disclosed
CN-102906132-A Polymerizable ionic liquids comprising aromatic carboxylate anions 3M INNOVATIVE PROPERTIES CO 2013-01-30 CN disclosed
CN-1816536-B Cannabinoid receptor modulators TAKAEDA CHEMICAL IND LTD 2012-12-26 CN disclosed
CN-1079396-C Aromatic amidine derivatives useful as selective thrombin inhibitors C & C RES LAB (KR) 2002-02-20 CN disclosed
CN-1298404-A Inhibitors of phospholipase A2 GENETICS INST (US) 2001-06-06 CN disclosed
CN-1288462-A Oxazolidinone combinatorial libraries, compositions and method of prepn. UPJOHN CO (US) 2001-03-21 CN disclosed
CN-1276727-A Growth hormone secretagogues LILLY CO ELI (US) 2000-12-13 CN disclosed
CN-1267296-A Barbituric acid derivatives with anti-metastatic and anti-tumor activities ROCH DIAGNOSIS EQUIPMENT AG (DE) 2000-09-20 CN disclosed
CN-1219932-A Aromatic amidine derivatives useful as selective thrombin inhibitors C & C RESEARCH LAB (KR) 1999-06-16 CN disclosed
CN-1209123-A New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same BOEHRINGER MANNHEIM GMBH (DE) 1999-02-24 CN disclosed
CN-1194580-A Ketone derivatives and medical use thereof TORAY INDUSTRIES (JP) 1998-09-30 CN disclosed