Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | TEK | Q02763 | 6/20 | 0.49 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27381319 | 0.92 | SRC (0.53) | SRCKDRTEKLCKABL1 | |
| SCHEMBL28825829 | 0.82 | DYRK3 (0.39) | SRCKDRTEKLCKABL1 | |
| SCHEMBL2074398 | 0.76 | PIK3CD (0.73) | SRCKDRTEKLCKABL1 | |
| SCHEMBL28814503 | 0.76 | FGFR2 (0.48) | — | |
| SCHEMBL27555108 | 0.73 | TEK (0.74) | SRCKDRTEKLCKEGFR | |
| SCHEMBL27378709 | 0.72 | PIK3CD (0.63) | SRCKDRLCKABL1EGFR | |
| SCHEMBL27399946 | 0.72 | PIK3CD (0.66) | SRCKDRLCKABL1EGFR | |
| SCHEMBL27535239 | 0.71 | SRC (0.58) | SRCKDRTEKLCKABL1 | |
| SCHEMBL8107904 | 0.69 | SRC (1.00) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL8107053 | 0.69 | SRC (0.90) | SRCKDRABL1EGFRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1079796-C | Novel N-7-heterocyclyl-pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 2002-02-27 | — | — | CN | disclosed |
| CN-1216544-A | Novel N-7-heterocyclyl pyrrolo [2,3-D] pyridines and their use | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |