Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | WRN | Q14191 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377081 | 0.91 | FPR2 (0.41) | MCHR1ENPP2KMT2AFPR2EPHX2 | |
| SCHEMBL27381122 | 0.90 | EPHX2 (0.38) | MCHR1ENPP2KMT2AFPR2EPHX2 | |
| SCHEMBL27381048 | 0.90 | EPHX2 (0.38) | MCHR1ENPP2KMT2AFPR2EPHX2 | |
| SCHEMBL27380972 | 0.89 | ENPP2 (0.39) | ENPP2KMT2AFPR2EPHX2WRN | |
| SCHEMBL27381045 | 0.89 | WRN (0.38) | ENPP2KMT2AFPR2EPHX2MEN1 | |
| SCHEMBL31005804 | 0.88 | KDM4E (0.39) | ENPP2KMT2AFPR2EPHX2WRN | |
| SCHEMBL27380776 | 0.87 | MCHR1 (0.37) | MCHR1ENPP2KMT2AFPR2EPHX2 | |
| SCHEMBL27377219 | 0.87 | EPHX2 (0.40) | ENPP2KMT2AFPR2EPHX2WRN | |
| SCHEMBL27381330 | 0.86 | PDE2A (0.37) | MCHR1ENPP2KMT2AFPR2EPHX2 | |
| SCHEMBL27381226 | 0.85 | ENPP2 (0.41) | ENPP2KMT2AMEN1WRNUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024105553-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS WRN INHIBITORS | NOVARTIS AG (CH) | 2024-05-23 | — | — | WO | disclosed |