Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994597 | 0.83 | SMN1; SMN2 (0.48) | KDM4ETDP1CLPP | |
| SCHEMBL30799033 | 0.83 | CYP11B2 (0.41) | MEN1KMT2APOLBPIK3CDMAPT | |
| SCHEMBL27385984 | 0.83 | CYP11B2 (0.41) | MEN1KMT2APOLBPIK3CDMAPT | |
| SCHEMBL13299412 | 0.82 | SMN1; SMN2 (0.49) | MEN1KMT2APOLBALDH1A1TP53 | |
| SCHEMBL1553262 | 0.82 | L3MBTL1 (0.54) | MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL8327744 | 0.78 | KMT2A (0.61) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL27383396 | 0.77 | L3MBTL1 (0.65) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL3154100 | 0.75 | POLB (0.67) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL14047746 | 0.75 | KMT2A (0.58) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL178443 | 0.75 | NCF1 (0.66) | ALDH1A1KDM4EHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |