Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27385984 | 1.00 | CYP11B2 (0.41) | CYP11B2CYP11B1HTR2CGRM2JAK2 | |
| SCHEMBL3994597 | 0.83 | SMN1; SMN2 (0.48) | CYP11B2CYP11B1GRM2JAK2 | |
| SCHEMBL27383401 | 0.83 | MEN1 (0.57) | PIK3CDMEN1POLBKMT2AMAPT | |
| SCHEMBL1553262 | 0.82 | L3MBTL1 (0.54) | JAK2SIGMAR1PRMT5WDR77MEN1 | |
| SCHEMBL15516474 | 0.78 | L3MBTL1 (0.58) | HTR2CFAAHSIGMAR1KMT2A | |
| SCHEMBL30799059 | 0.77 | L3MBTL1 (0.65) | HTR2CFAAHSIGMAR1 | |
| SCHEMBL14047566 | 0.75 | HTR2C (0.41) | HTR2CFAAHSIGMAR1MEN1POLB | |
| SCHEMBL31512198 | 0.75 | L3MBTL1 (0.68) | HTR2CFAAHSIGMAR1KMT2A | |
| SCHEMBL27165584 | 0.75 | L3MBTL1 (0.68) | HTR2CFAAHSIGMAR1KMT2A | |
| SCHEMBL807251 | 0.75 | NCF1 (0.66) | HIF1AEPAS1NCF1FAAHSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |