Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.65 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.65 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.62 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.62 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.62 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674558 | 0.88 | KCNK3 (0.71) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL3677300 | 0.85 | KMT2A (0.59) | MEN1KMT2AKCNK3KCNK9RAB9A | |
| SCHEMBL3786882 | 0.85 | KCNK3 (0.87) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL12685658 | 0.84 | RHOC (0.57) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL13802448 | 0.84 | MEN1 (0.78) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL2565385 | 0.84 | TP53 (0.78) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL8363018 | 0.84 | SMN1; SMN2 (0.76) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL3454686 | 0.84 | MEN1 (0.65) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL3675463 | 0.83 | KCNK3 (0.84) | MEN1KMT2AMAPTHTTKCNK3 | |
| SCHEMBL22103906 | 0.83 | MEN1 (0.63) | MEN1KMT2AMAPTHTTKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |