SCHEMBL3674558

SCHEMBL3674558

O=C(Nc1ccc(Cl)cc1)c1cccc(Cl)c1

nearest known ligand 0.72

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 2/20 0.71
KCNK9 Q9NPC2 2/20 0.71
MEN1 O00255 3/20 0.70
KMT2A Q03164 3/20 0.70
MAPT P10636 2/20 0.70
HTT P42858 1/20 0.70
KCNQ3 O43525 2/20 0.68
KCNQ2 O43526 2/20 0.68
KCNE1 P15382 2/20 0.68
KCNQ1 P51787 2/20 0.68
RAB9A P51151 6/20 0.67
NPC1 O15118 5/20 0.67
KDM4E B2RXH2 1/20 0.67
KCNQ5 Q9NR82 1/20 0.67
SMN1; SMN2 Q16637 2/20 0.65
RXFP1 Q9HBX9 1/20 0.64
KCNMA1 Q12791 1/20 0.64
TP53 P04637 1/20 0.62
HPGD P15428 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3786882 0.89 KCNK3 (0.87) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL2565385 0.88 TP53 (0.78) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL27383416 0.88 MEN1 (0.65) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL3454686 0.88 MEN1 (0.65) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL8363018 0.88 SMN1; SMN2 (0.76) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL13802448 0.88 MEN1 (0.78) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL3675463 0.87 KCNK3 (0.84) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL3667947 0.87 PGR (0.64) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL22103906 0.87 MEN1 (0.63) KCNK3KCNK9MEN1KMT2AMAPT
SCHEMBL12218356 0.85 RAB9A (0.73) KCNK3KCNK9MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
US-6897316-B2 Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents CHINA MEDICAL UNIVERSITY (TW) 2005-05-24 US disclosed
US-20050032832-A1 Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents CHINA MEDICAL UNIVERSITY (TW) 2005-02-10 US disclosed
EP-1245554-B1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORP (JP) 2005-01-26 EP disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6794480-B2 POLYARYLENE-BASED COPOLYMER USEFUL AS PROTON-CONDUCTIVE MEMBRANE WHICH CAN BE USED AS ELECTRON FOR PRIMARY BATTERY, ELECTROLYTE FOR SECONDARY BATTERY, HIGH MOLECULAR SOLID ELECTROLYTE FOR FUEL CELL JSR CORPORATION (JP) 2004-09-21 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-20020177656-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORPORATION (JP) 2002-11-28 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
EP-1245554-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050032832-A1 Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CHUK KCNK3 3736/4885KCNK9 4480/4885MEN1 3877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.