Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788828 | 0.80 | SYK (0.33) | GRM5SYK | |
| SCHEMBL28311822 | 0.78 | AURKA (0.40) | SYKALDH1A1L3MBTL1 | |
| SCHEMBL23887607 | 0.76 | SYK (0.42) | GRM5SYKALDH1A1 | |
| SCHEMBL9461070 | 0.76 | MEN1 (0.33) | ALDH1A1 | |
| SCHEMBL28726329 | 0.76 | SORT1 (0.41) | GRM5 | |
| SCHEMBL27963043 | 0.74 | ESR1 (0.41) | ALDH1A1 | |
| SCHEMBL29213157 | 0.73 | — | — | |
| SCHEMBL1782191 | 0.72 | — | — | |
| SCHEMBL31205727 | 0.72 | — | — | |
| SCHEMBL445950 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067888-A | 2-piperidinyl pyrimidine-4-carboxamides derivatives and method for making and medical applications | SYNTHELABO (FR) | 1993-01-13 | — | — | CN | claimed |
| CN-1067887-A | 2-aminopyrimidine-4-carboxamides derivatives and method for making and medical applications | SYNTHELABO (FR) | 1993-01-13 | — | — | CN | claimed |
| CN-1067884-A | Pyrimidine-4-carboxamides derivatives and method for making and medical applications | SYNTHELABO (FR) | 1993-01-13 | — | — | CN | claimed |
| CN-1066066-A | 2-aminopyrimidine-4-carboxamides derivatives, its synthetic method and application aspect medical | SYNTHELABO (FR) | 1992-11-11 | — | — | CN | claimed |
| CN-110198934-A | PYRIMIDINE CARBOXAMIDES AS GSK-3 INHIBITORS | 百时美施贵宝公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-105085491-B | Substituted benzazolyl compounds and its application method and purposes | 广东东阳光药业有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-106414448-B | It can be used as the new compound of S100- inhibitor | 活跃生物技术有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-105085482-B | Substituted diethylenediamine compound and its application method and purposes | 广东东阳光药业有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-105461635-B | Phenylpiperazine derivatives and its application method and purposes | 乳源瑶族自治县大众药品贸易有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-105073742-B | FLAP conditioning agents | 詹森药业有限公司 | 2017-08-08 | — | — | CN | disclosed |
| CN-106794181-A | MTH1 inhibitors for the treatment of inflammatory and autoimmune conditions | 托马斯·黑勒戴药物研究基金会 | 2017-05-31 | — | — | CN | disclosed |
| CN-105658639-A | Alkynyl alcohols and methods of use | 豪夫迈·罗氏有限公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-101573033-A | Heterocyclyl-substituted anti-hypercholesterolemic compounds | MERCK & CO INC (US) | 2009-11-04 | — | — | CN | disclosed |
| CN-1067888-A | 2-piperidinyl pyrimidine-4-carboxamides derivatives and method for making and medical applications | SYNTHELABO (FR) | 1993-01-13 | — | — | CN | disclosed |
| CN-1067887-A | 2-aminopyrimidine-4-carboxamides derivatives and method for making and medical applications | SYNTHELABO (FR) | 1993-01-13 | — | — | CN | disclosed |
| CN-1067884-A | Pyrimidine-4-carboxamides derivatives and method for making and medical applications | SYNTHELABO (FR) | 1993-01-13 | — | — | CN | disclosed |
| CN-1066066-A | 2-aminopyrimidine-4-carboxamides derivatives, its synthetic method and application aspect medical | SYNTHELABO (FR) | 1992-11-11 | — | — | CN | disclosed |