Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.44 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.44 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27384820 | 0.94 | POLB (0.46) | POLBKMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL27384836 | 0.83 | POLB (0.52) | POLBKMT2AMAPK1ALDH1A1HPGD | |
| SCHEMBL27385009 | 0.81 | ALDH1A1 (0.49) | POLBKMT2AALDH1A1HPGDCYP1A2 | |
| SCHEMBL11165259 | 0.81 | MAP2K4 (0.44) | POLBKMT2AMAPK1MAP2K4MAPK6 | |
| SCHEMBL11158785 | 0.81 | KMT2A (0.45) | POLBKMT2AMAPK1MAP2K4HPGD | |
| SCHEMBL11170339 | 0.80 | PRKAG1 (0.56) | POLBKMT2AALDH1A1HPGDCYP1A2 | |
| SCHEMBL1406065 | 0.80 | MAP2K4 (0.61) | KMT2AMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL12090187 | 0.80 | MAPK1 (0.50) | MAPK1MAP2K4MAPKAPK3MAPK6PRKAG1 | |
| SCHEMBL2446205 | 0.78 | KDM4E (0.65) | POLBKMT2AMAPK1ALDH1A1HPGD | |
| SCHEMBL25839255 | 0.78 | CHEK1 (0.44) | MAPK1MAP2K4MAPKAPK3MAPK6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | MIRATI THERAPEUTICS INC (US) | 2024-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | PRMT1, PRMT5, PRMT6 | POLB 702/4885KMT2A 165/4885MAPK1 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.