Proflavine

Proflavine

SCHEMBL27386

Nc1ccc2cc3ccc(N)cc3nc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 1.00
LMNA P02545 3/20 1.00
HTT P42858 3/20 1.00
MEN1 O00255 3/20 1.00
ACHE P22303 2/20 1.00
F2 P00734 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
MAOA P21397 1/20 1.00
DRD1 P21728 1/20 1.00
PTGS1 P23219 1/20 1.00
SLC6A2 P23975 1/20 1.00
SLC6A4 P31645 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
KDR P35968 1/20 1.00
SLC6A3 Q01959 1/20 1.00
KCNH2 Q12809 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proflavine SCHEMBL29600097 1.00 KMT2A (1.00) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL10380090 0.97 KMT2A (0.95) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL664629 0.97 KMT2A (0.95) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL865664 0.97 KMT2A (0.95) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL28534424 0.95 KMT2A (0.90) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL1679313 0.93 KMT2A (0.86) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL28419396 0.91 KMT2A (0.82) KMT2ALMNAHTTMEN1ACHE
SCHEMBL5394789 0.91 KMT2A (0.82) KMT2ALMNAHTTMEN1ACHE
SCHEMBL31473182 0.91 KMT2A (0.82) KMT2ALMNAHTTMEN1ACHE
SCHEMBL1229699 0.89 HTR3A (1.00) KMT2ALMNAHTTMEN1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11469 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137806-A1 INTERCALATING SUGAR MOLECULES XALUD THERAPEUTICS, INC. (US) 2026-05-21 US claimed
CN-122056886-A Application of proflavine and derivative thereof in preparation of METTL B inhibitor 深圳市人民医院 2026-05-19 CN claimed
EP-4737898-A2 SEPARATION AND ISOLATION OF NUCLEIC ACIDS USING AFFINITY LIGANDS BOUND TO A SOLID SURFACE EMP Biotech GmbH (DE) 2026-05-06 EP claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260069175-A1 SAMPLE-TO-ANSWER DIAGNOSTIC SYSTEM FOR THE DETECTION OF CIRCULATING HISTONES IN WHOLE BLOOD UNIV MARYLAND (US) 2026-03-12 US claimed
US-20260048152-A1 GEMCITABINE INORGANIC-ORGANIC HYBRID NANOPARTICLES KARLSRUHER INSTITUT FUER TECH KOERPERSCHAFT DES OEFFENTLICHEN RECHTS (DE) 2026-02-19 US claimed
EP-4696341-A1 MEDICAL DEVICE AND SYSTEM, AND PREPARATION METHOD Shanghai MicroPort Medical (Group) Co., Ltd. (CN) 2026-02-18 EP claimed
US-12551149-B2 Sample-to-answer diagnostic system for the detection of circulating histones in whole blood UNIVERSITY OF MARYLAND, COLLEGE PARK (US) 2026-02-17 US claimed
EP-4683967-A1 LABELLED PARTICLES COSA Group GmbH (DE) 2026-01-28 EP claimed
WO-2025233674-A1 ANTIMICROBIAL COMPOSITIONS: METHODS OF MAKING AND USING THE SAME ZONOVA TECHNOLOGIES LTD (GB) 2025-11-13 WO claimed
US-4591379-A 3,6-DIAMINO-ACRIDINE N-GLYCOSIDES BIOGAL GYOGYSZERGYAR (HU) 1986-05-27 US claimed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 EP claimed
EP-0163316-A1 Platinum-intercalative complexes for the treatment of cancer MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1985-12-04 EP claimed
EP-0141628-A1 Antimicrobial latex composition shaped article produced therefrom, and method of manufacturing a shaped article UNITIKA LTD. (JP) 1985-05-15 EP claimed
US-4508738-A CURING REMOVAL OF PLASMID;STORGE STABILITY MICROLIFE TECHNICS, INC. (US) 1985-04-02 US claimed
EP-0088880-A2 Non-sucrose fermenting Pediococcus pentosaceus MICROLIFE GENETICS, INC. (US) 1983-09-21 EP claimed
US-4382846-A IRRADIATION; PHOTOSENSITIZER, ELECTRON RELAY, REDOX CATALYST ENGELHARD CORPORATION (US) 1983-05-10 US claimed
US-4257774-A Intercalation inhibition assay for compounds that interact with DNA or RNA MELOY LABORATORIES, INC. (US) 1981-03-24 US claimed
US-4242499-A Colored polymers comprising poly(organophosphazenes) with chromophores as substituent groups THE FIRESTONE TIRE & RUBBER COMPANY (US) 1980-12-30 US claimed
US-4189423-A DIMENSIONAL STABILIZATION BY ADDING A DI(HALO-ISOINDOLO) AROMATIC COMPOUND OR MIXTURE WITH A PIGMENT TOYO INK MANUFACTURING CO., LTD. (JP) 1980-02-19 US claimed