Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Proflavine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.95 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.95 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.95 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.95 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.95 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.95 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.95 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.95 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.95 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.95 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.95 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.95 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.95 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.95 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.75 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.48 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 known ✓ | P08238 | 1/20 | 0.45 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proflavine SCHEMBL865664 | 1.00 | KMT2A (0.95) | KMT2ALMNAHTTMEN1ACHE | |
| Proflavine SCHEMBL10380090 | 1.00 | KMT2A (0.95) | KMT2ALMNAHTTMEN1ACHE | |
| Proflavine SCHEMBL28534424 | 0.97 | KMT2A (0.90) | KMT2ALMNAHTTMEN1ACHE | |
| Proflavine SCHEMBL27386 | 0.97 | KMT2A (1.00) | KMT2ALMNAHTTMEN1ACHE | |
| Proflavine SCHEMBL29600097 | 0.97 | KMT2A (1.00) | KMT2ALMNAHTTMEN1ACHE | |
| Proflavine SCHEMBL1679313 | 0.90 | KMT2A (0.86) | KMT2ALMNAHTTMEN1ACHE | |
| Proflavine SCHEMBL28419396 | 0.88 | KMT2A (0.82) | KMT2ALMNAHTTMEN1ACHE | |
| SCHEMBL5394789 | 0.88 | KMT2A (0.82) | KMT2ALMNAHTTMEN1ACHE | |
| SCHEMBL31473182 | 0.88 | KMT2A (0.82) | KMT2ALMNAHTTMEN1ACHE | |
| Hydrochloric Acid SCHEMBL28534457 | 0.87 | HTR3A (0.92) | KMT2ALMNAHTTMEN1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111712584-B | Enhancement of nucleic acid polymerization by minor groove binding moieties | F·霍夫曼-罗氏股份公司 | 2025-02-07 | — | — | CN | claimed |
| CN-113121728-B | Phosphorescent material and preparation method thereof | 华东理工大学 | 2021-12-07 | — | — | CN | claimed |
| CN-113121728-A | Phosphorescent material and preparation method thereof | 华东理工大学 | 2021-07-16 | — | — | CN | claimed |
| CN-112336864-A | Application of proflavine in lung cancer treatment | 厦门大学 | 2021-02-09 | — | — | CN | claimed |
| US-9575226-B2 | Positive microcontact printing | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2017-02-21 | — | — | US | claimed |
| US-20160085000-A1 | POSITIVE MICROCONTACT PRINTING | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2016-03-24 | — | — | US | claimed |
| EP-2350617-A2 | A METHOD AND APPARATUS FOR ANALYSIS OF A PARTICLE | ChemoMetec A/S (DK) | 2011-08-03 | — | — | EP | claimed |
| WO-2010045949-A2 | A METHOD AND APPARATUS FOR ANALYSIS OF A PARTICLE | CHEMOMETEC A/S (DK) | 2010-04-29 | — | — | WO | claimed |
| EP-1575540-A1 | AGENT FOR DYING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004058200-A1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-07-15 | — | — | WO | claimed |
| US-5652093-A | Analogues of reporter groups as background reducers in binding assays | APROGENEX, INC. (US) | 1997-07-29 | — | — | US | claimed |
| EP-0743574-A2 | Migration imaging members | XEROX CORPORATION (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743573-A2 | Method for obtaining image contrast migration imaging members | XEROX CORPORATION (US) | 1996-11-20 | — | — | EP | claimed |
| US-5563014-A | SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT | XEROX CORPORATION (US) | 1996-10-08 | — | — | US | claimed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | claimed |
| EP-0431452-B1 | Method for the optical distinction of dental materials and material used in this method | IVOCLAR AG (LI) | 1994-10-05 | — | — | EP | claimed |
| US-5102461-A | PROCESS FOR THE OPTICAL DISTINCTION OF A DENTAL MATERIAL AND DENTAL MATERIAL FOR SAID PROCESS | IVOCLAR AG (DE) | 1992-04-07 | — | — | US | claimed |
| EP-0431452-A2 | Method for the optical distinction of dental materials and material used in this method | IVOCLAR AG (LI) | 1991-06-12 | — | — | EP | claimed |
| US-4900721-A | Disinfectants and their use for disinfecting the skin and mucous membrane | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1990-02-13 | — | — | US | claimed |
| EP-0331052-A2 | Process for the preparation of imidized acrylic polymers | ELF ATOCHEM ITALIA S.r.l. (IT) | 1989-09-06 | — | — | EP | claimed |