SCHEMBL1229699

SCHEMBL1229699

Nc1ccc2cc3ccccc3nc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 1/20 1.00
KMT2A Q03164 6/20 0.78
MEN1 O00255 4/20 0.78
LMNA P02545 3/20 0.78
ACHE P22303 2/20 0.78
HTT P42858 2/20 0.78
F2 P00734 1/20 0.78
CHRM2 P08172 1/20 0.78
HTR1A P08908 1/20 0.78
ADRA2A P08913 1/20 0.78
ADORA3 P0DMS8 1/20 0.78
MAOA P21397 1/20 0.78
DRD1 P21728 1/20 0.78
PTGS1 P23219 1/20 0.78
SLC6A2 P23975 1/20 0.78
SLC6A4 P31645 1/20 0.78
OPRM1 P35372 1/20 0.78
DRD3 P35462 1/20 0.78
KDR P35968 1/20 0.78
SLC6A3 Q01959 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proflavine SCHEMBL3864747 1.00 HTR3A (1.00) HTR3AKMT2AMEN1LMNAACHE
Proflavine SCHEMBL28321972 0.98 HTR3A (0.96) HTR3AKMT2AMEN1LMNAACHE
Hydrochloric Acid SCHEMBL28534457 0.96 HTR3A (0.92) HTR3AKMT2AMEN1LMNAACHE
Alcohol SCHEMBL29120969 0.89 HTR3A (0.79) HTR3AKMT2AMEN1LMNAACHE
Proflavine SCHEMBL27386 0.89 KMT2A (1.00) HTR3AKMT2AMEN1LMNAACHE
Proflavine SCHEMBL29600097 0.89 KMT2A (1.00) HTR3AKMT2AMEN1LMNAACHE
Sulfuric Acid SCHEMBL28530710 0.88 HTR3A (0.77) HTR3AKMT2AMEN1LMNAACHE
SCHEMBL30076611 0.87 HTR3A (0.77) HTR3AKMT2AMEN1LMNAACHE
SCHEMBL1230201 0.87 HTR3A (0.77) HTR3AKMT2AMEN1LMNAACHE
Proflavine SCHEMBL11072089 0.86 KMT2A (0.77) HTR3AKMT2AMEN1LMNAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210222226-A1 METHODS OF MEASURING ENZYME ACTIVITY IN COATING COMPOSTIONS BASF SE (DE) 2021-07-22 US claimed
EP-3814518-A1 METHODS OF MEASURING ENZYME ACTIVITY IN COATING COMPOSITIONS BASF SE (DE) 2021-05-05 EP claimed
CN-108522268-A A kind of method for mutation breeding of buckwheat 庆阳敦博科技发展有限公司 2018-09-14 CN claimed
US-7261857-B2 Colorimetric artificial nose having an array of dyes and method for artificial olfaction THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2007-08-28 US claimed
US-20030143112-A1 Colorimetric artificial nose having an array of dyes and method for artificial olfaction BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2003-07-31 US claimed
EP-0397474-A2 Photosensitive composition KABUSHIKI KAISHA TOSHIBA (JP) 1990-11-14 EP claimed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 EP disclosed
US-12038429-B2 Detection of drug resistance of microorganisms SPECIFIC DIAGNOSTICS, LLC (US) 2024-07-16 US disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 US disclosed
CN-117004383-A Long afterglow material and preparation method and application thereof 中山大学 2023-11-07 CN disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 US disclosed
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2023-04-20 US disclosed
EP-4166677-A1 DETECTION OF DRUG RESISTANCE OF MICROORGANISMS Specific Technologies, LLC (US) 2023-04-19 EP disclosed
US-4766110-A INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS RYAN JAMES W (US) 1988-08-23 US disclosed
EP-0073143-B1 NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES Ryan, James Walter (US) 1985-11-21 EP disclosed
US-4462993-A REACTION WITH A SUGAR IN PRESENCE OF ACID CATALYST BIOGAL GYOGYSZERGYAR (HU) 1984-07-31 US disclosed
US-4452720-A Fluorescent composition having the ability to change wavelengths of light, shaped article of said composition as a light wavelength converting element and device for converting optical energy to electrical energy using said element TEIJIN LIMITED (JP) 1984-06-05 US disclosed
EP-0073143-A2 Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides Ryan, James Walter (US) 1983-03-02 EP disclosed
EP-0041274-A1 Fluorescent composition having the ability to change wavelengths of light, shaped article of said composition as a light wavelength converting element, and device for converting optical energy to electrical energy using said element TEIJIN LIMITED (JP) 1981-12-09 EP disclosed
US-4060527-A MICROBIOCIDE FUJI CHEMICAL INDUSTRIES, LTD. (JA) 1977-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 HTR3A 3631/4885KMT2A 3136/4885MEN1 4821/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 HTR3A 2099/4885KMT2A 4144/4885MEN1 2694/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 HTR3A 2099/4885KMT2A 4144/4885MEN1 2694/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.