Proflavine

Proflavine

SCHEMBL28419396

N=[N+]=N.Nc1ccc2cc3ccc(N)cc3nc2c1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.82
LMNA P02545 3/20 0.82
HTT P42858 3/20 0.82
MEN1 O00255 3/20 0.82
ACHE P22303 2/20 0.82
F2 P00734 1/20 0.82
CHRM2 P08172 1/20 0.82
HTR1A P08908 1/20 0.82
ADRA2A P08913 1/20 0.82
ADORA3 P0DMS8 1/20 0.82
MAOA P21397 1/20 0.82
DRD1 P21728 1/20 0.82
PTGS1 P23219 1/20 0.82
SLC6A2 P23975 1/20 0.82
SLC6A4 P31645 1/20 0.82
OPRM1 P35372 1/20 0.82
DRD3 P35462 1/20 0.82
KDR P35968 1/20 0.82
SLC6A3 Q01959 1/20 0.82
KCNH2 Q12809 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proflavine SCHEMBL29600097 0.91 KMT2A (1.00) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL27386 0.91 KMT2A (1.00) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL664629 0.88 KMT2A (0.95) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL865664 0.88 KMT2A (0.95) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL10380090 0.88 KMT2A (0.95) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL28534424 0.86 KMT2A (0.90) KMT2ALMNAHTTMEN1ACHE
Proflavine SCHEMBL1679313 0.84 KMT2A (0.86) KMT2ALMNAHTTMEN1ACHE
SCHEMBL5394789 0.82 KMT2A (0.82) KMT2ALMNAHTTMEN1ACHE
SCHEMBL31473182 0.82 KMT2A (0.82) KMT2ALMNAHTTMEN1ACHE
SCHEMBL1229699 0.80 HTR3A (1.00) KMT2ALMNAHTTMEN1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111566212-A miRNA molecules, equivalents, antanemia or sources thereof for use in the treatment and/or diagnosis of disorders and/or diseases associated with neuronal defects or for use in neuronal generation and/or regeneration 因特尔纳技术有限公司 2020-08-21 CN disclosed
CN-111386121-A Nucleic acid molecules with anti-inflammatory, anticoagulant and organ protective properties 阿帕塔姆公司 2020-07-07 CN disclosed