5-Hydroxy-Diclofenac

5-Hydroxy-Diclofenac

SCHEMBL2738864

O=C(O)Cc1cc(O)ccc1Nc1c(Cl)cccc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CAMK2A Q9UQM7 4/20 1.00
PTGS2 P35354 8/20 0.75
TTR P02766 3/20 0.71
PTGS1 P23219 3/20 0.71
ABCB11 O95342 2/20 0.71
NR1I3 Q14994 2/20 0.71
CXCL8 P10145 2/20 0.71
AKR1B10 O60218 1/20 0.71
UGT1A9 O60656 1/20 0.71
TRPA1 O75762 1/20 0.71
MT-CO2 P00403 1/20 0.71
ALB P02768 1/20 0.71
UGT1A6 P19224 1/20 0.71
UGT1A1 P22309 1/20 0.71
CXCR1 P25024 1/20 0.71
ADRA1A P35348 1/20 0.71
AGTR2 P50052 1/20 0.71
SLC22A6 Q4U2R8 1/20 0.71
NR1H4 Q96RI1 1/20 0.71
UGT1A7 Q9HAW7 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4',5-Dihydroxy-Diclofenac SCHEMBL7162002 0.90 CAMK2A (0.81) CAMK2APTGS2TTRPTGS1ABCB11
SCHEMBL1031733 0.86 PTGS2 (1.00) CAMK2APTGS2TTRPTGS1ABCB11
SCHEMBL10796562 0.86 CAMK2A (0.75) CAMK2APTGS2TTRPTGS1ABCB11
SCHEMBL23691079 0.86 TTR (0.76) CAMK2APTGS2TTRPTGS1ABCB11
SCHEMBL6036623 0.83 PTGS2 (0.72) CAMK2APTGS2TTRPTGS1ABCB11
Diclofenac SCHEMBL2799 0.83 PTGS2 (1.00) CAMK2APTGS2TTRPTGS1ABCB11
Diclofenac SCHEMBL29354260 0.83 PTGS2 (1.00) CAMK2APTGS2TTRPTGS1ABCB11
Diclofenac SCHEMBL996716 0.83 PTGS2 (1.00) CAMK2APTGS2TTRPTGS1ABCB11
SCHEMBL7165893 0.82 PTGS2 (0.70) CAMK2APTGS2TTRPTGS1ABCB11
Diclofenac SCHEMBL3184302 0.82 PTGS2 (0.97) CAMK2APTGS2TTRPTGS1ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240299450-A1 USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS THEREFOR Elicio Therapeutics, Inc. 2024-09-12 US claimed
CN-117766159-A Non-steroidal anti-inflammatory drug and liver toxicity risk assessment method of metabolite thereof based on network architecture analysis 重庆医科大学 2024-03-26 CN claimed
EP-4304638-A1 USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS THEREFOR Elicio Therapeutics, Inc. (US) 2024-01-17 EP claimed
WO-2022192524-A1 USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS THEREFOR Elicio Therapeutics, Inc. (US) 2022-09-15 WO claimed
EP-4735027-A1 GENETICALLY ENGINEERED MUCOSAL-ASSOCIATED INVARIANT T (MAIT) CELLS FOR ADOPTIVE TRANSFER CELLTHERAPY Pluri Biotech Ltd. (IL) 2026-05-06 EP disclosed
US-20260071180-A1 GENETICALLY ENGINEERED PLACENTAL MUCOSALASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF PLURI BIOTECH LTD (IL) 2026-03-12 US disclosed
US-20260062672-A1 GENETICALLY ENGINEERED PLACENTAL MUCOSALASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF PLURI BIOTECH LTD (IL) 2026-03-05 US disclosed
US-20250388875-A1 BIOCATALYTIC TECHNIQUES HYPHA DISCOVERY LIMITED (GB) 2025-12-25 US disclosed
US-20250290039-A1 GENETICALLY ENGINEERED PLACENTAL MUCOSALASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF PLURI BIOTECH LTD (IL) 2025-09-18 US disclosed
US-20250288667-A1 GENETICALLY ENGINEERED MUCOSAL-ASSOCIATED INVARIANT T (MAIT) CELLS FOR ADOPTIVE TRANSFER CELLTHERAPY PLURI BIOTECH LTD (IL) 2025-09-18 US disclosed
US-12410411-B2 Biocatalytic techniques HYPHA DISCOVERY LIMITED (GB) 2025-09-09 US disclosed
EP-4572789-A1 GENETICALLY ENGINEERED PLACENTAL MUCOSAL-ASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF Pluri Biotech Ltd. (IL) 2025-06-25 EP disclosed
US-8088918-B2 Noncardiotoxic pharmaceutical compounds WILLIAMSBURG HOLDINGS LLC (US) 2012-01-03 US disclosed
US-20080045564-A1 QUININE PRODUCTS, METHOD OF MANUFACTURE, METHOD OF USE MUTUAL PHARMACEUTICAL COMPANY, INC. (US) 2008-02-21 US disclosed
US-20080039492-A1 Quinine products, method of manufacture, and method of use MUTUAL PHARMACEUTICAL COMPANY, INC., A PENNSYLVANIA CORPORATION 2008-02-14 US disclosed
WO-2008013773-A2 QUININE PRODUCTS, METHOD OF MANUFACTURE, AND METHOD OF USE MUTUAL PHARMACEUTICAL COMPANY, INC. (US) 2008-01-31 WO disclosed
WO-2004091522-A2 METHOD FOR TREATING NEURODEGENERATIVE DISORDERS MYRIAD GENETICS, INC. (US) 2004-10-28 WO disclosed
US-6552077-B2 Kidney disorders EXOCELL, INC. 2003-04-22 US disclosed
US-6355680-B1 BLOCKING REACTION OF GLUCOSE AND ALBUMIN EXOCELL, INC. 2002-03-12 US disclosed
US-20010034359-A1 Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies EXOCELL, INC. 2001-10-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260071180-A1 GENETICALLY ENGINEERED PLACENTAL MUCOSALASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF CD74, CD4, IL2RA CAMK2A 1568/4885PTGS2 1731/4885TTR 2363/4885
US-20010034359-A1 Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies ALB, AGER, TTR CAMK2A 2988/4885PTGS2 2067/4885TTR 3/4885
US-20240299450-A1 USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS THEREFOR CD4, CD74, CD47 CAMK2A 3082/4885PTGS2 4065/4885TTR 3319/4885
US-20250388875-A1 BIOCATALYTIC TECHNIQUES CYP2C9, CYC1, CYBA CAMK2A 3725/4885PTGS2 2106/4885TTR 878/4885
US-20260062672-A1 GENETICALLY ENGINEERED PLACENTAL MUCOSALASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF CD4, CD74, IL2RA CAMK2A 1137/4885PTGS2 1722/4885TTR 3163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.