Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187224 | 1.00 | SLC6A4 (0.67) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL7184970 | 1.00 | SLC6A4 (0.67) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL2314 | 0.98 | SLC6A4 (0.65) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL7170390 | 0.86 | SLC6A4 (0.54) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL8167375 | 0.85 | SLC6A4 (0.67) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL2644 | 0.84 | CYP3A4 (0.58) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL9117724 | 0.84 | SLC6A4 (0.65) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL14089440 | 0.82 | SLC6A4 (0.60) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL14089422 | 0.82 | SLC6A4 (0.60) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL7550873 | 0.81 | SLC6A3 (0.49) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103819632-B | A kind of sibutramine magnetic molecularly imprinted polymer and preparation method thereof | 南京医科大学 | 2016-07-06 | — | — | CN | claimed |
| CN-105636438-A | Pharmaceutical composition comprising an AMPK activator and a serotonin active agent and uses thereof | CHEN JIANHONG | 2016-06-01 | — | — | CN | claimed |
| EP-2983473-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS Mountain Llc (US) | 2016-02-17 | — | — | EP | claimed |
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | claimed |
| WO-2014144130-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC (US) | 2014-09-18 | — | — | WO | claimed |
| CN-103819632-A | Sibutramine magnetic molecularly imprinted polymer and preparation method thereof | UNIV NANJING MEDICAL | 2014-05-28 | — | — | CN | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| US-20080161407-A1 | METHODS FOR TREATING METABOLIC SYNDROME | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | US | claimed |
| US-20080081826-A1 | SYSTEM FOR EFFECTING WEIGHT LOSS | ABBOTT LABORATORIES | 2008-04-03 | — | — | US | claimed |
| EP-1653911-A2 | METHODS FOR TREATING METABOLIC SYNDROME | Abbott Laboratories (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2000056318-A1 | TREATMENT OF NEUROPATHIC PAIN OR FIBROMYALGIA | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056321-A1 | TREATMENT OF HYPERACTIVITY DISORDERS | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056150-A1 | TREATMENT OF PREMENSTRUAL SYNDROME | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056312-A1 | TREATMENT OF PULMONARY HYPERTENSION | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056313-A1 | METHOD OF CONTROLLING WEIGHT GAIN ASSOCIATED WITH THERAPEUTIC DRUGS | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056317-A1 | WEIGHT LOSS AFTER PREGNANCY | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | claimed |
| WO-2000054765-A1 | METHOD OF TREATING EATING DISORDERS | KNOLL GMBH (DE) | 2000-09-21 | — | — | WO | claimed |
| US-6046242-A | ADMINISTERING TO A PATIENT AN EFFECTIVE AMOUNT OF CHLOROBENZENE SUBSTITUTED CYCLOBUTYLALKYLAMINE COMPOUND TO TREAT URINARY INCONTINENCE | BASF AKTIENGESELLSCHAFT (DE) | 2000-04-04 | — | — | US | claimed |
| WO-1995021615-A1 | USE OF ARYLCYCLOBUTYLALKYLAMINES FOR THE TREATMENT OF SEIZURES AND NEUROLOGICAL DISORDERS | KNOLL AG (DE) | 1995-08-17 | — | — | WO | claimed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161407-A1 | METHODS FOR TREATING METABOLIC SYNDROME | GPR119, CPT1A, GYS2 | SLC6A4 767/4885SLC6A3 1417/4885SLC6A2 556/4885 |
| US-20080081826-A1 | SYSTEM FOR EFFECTING WEIGHT LOSS | GIPR, MGLL, GLP1R | SLC6A4 746/4885SLC6A3 696/4885SLC6A2 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.