Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.98 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.98 |
| ▸ | USP2 | O75604 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.98 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.95 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroxicam SCHEMBL29352427 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL15741898 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL29396075 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL13462 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL28536166 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL2680486 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6759456 | 0.98 | KDM4E (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6942519 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL5084571 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL8908556 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1091428-A | 4-hydroxy-2-methyl-N-2-pyridine base-2H-1,2-benzothiazine-3-carboxamide-1, derivative of 1-dioxy and preparation method thereof | HENAN MEDICINE IND I (CN) | 1994-08-31 | — | — | CN | disclosed |