Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.98 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.98 |
| ▸ | USP2 | O75604 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.98 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.95 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroxicam SCHEMBL28536166 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL29352427 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL29396075 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL15741898 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL2680486 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL13462 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6759456 | 0.98 | KDM4E (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6942519 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL5084571 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL27394226 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115190878-B | Crystalline hydrates of JAK inhibitor compounds | 施万生物制药研发IP有限责任公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-117064898-A | Application of pirenoxine sodium in preparing antitumor drug | 江西中医药大学 | 2023-11-17 | — | — | CN | disclosed |
| CN-112739697-B | Dimethylaminoazetidine amides as JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-112703037-B | 5-to 7-membered heterocyclic amides as JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116507327-A | Chewable formulations | 礼蓝动物保健有限公司 | 2023-07-28 | — | — | CN | disclosed |
| US-5641504-A | TRANSDERMAL DRUG DELIVERY | ALZA CORPORATION (US) | 1997-06-24 | — | — | US | disclosed |
| US-5378730-A | Transdermal delivery of lidocaine | ALZA CORPORATION (US) | 1995-01-03 | — | — | US | disclosed |
| WO-1992020377-A1 | SKIN PERMEATION ENHANCER COMPOSITIONS USING GLYCEROL MONOLINOLEATE | ALZA CORPORATION (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0123520-B1 | PROCESS FOR PREPARING BASE SALTS OF PIROXICAM DEPOSITED ON A PHARMACEUTICALLY-ACCEPTABLE CARRIER | PFIZER INC. (US) | 1988-08-17 | — | — | EP | disclosed |
| EP-0123520-A1 | Process for preparing base salts of piroxicam deposited on a pharmaceutically-acceptable carrier | PFIZER INC. (US) | 1984-10-31 | — | — | EP | disclosed |