Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.98 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.98 |
| ▸ | USP2 | O75604 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.98 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.95 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroxicam SCHEMBL29396075 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL29352427 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL13462 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL15741898 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL28536166 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL2680486 | 0.99 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6759456 | 0.98 | KDM4E (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL5084571 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL8908556 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL27394226 | 0.98 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118555971-A | Amorphous photosensitive particles, methods of making and methods of using the same | 马里兰大学帕克分校 | 2024-08-27 | — | — | CN | claimed |
| CN-112174966-B | New method for preparing piroxicam hydrochloride | 重庆圣华曦药业股份有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-118555971-A | Amorphous photosensitive particles, methods of making and methods of using the same | 马里兰大学帕克分校 | 2024-08-27 | — | — | CN | disclosed |
| CN-112384223-B | Pharmaceutical composition containing poorly soluble basic agent | 中外制药株式会社 | 2024-08-27 | — | — | CN | disclosed |
| CN-118320013-A | Traditional Chinese medicine composition for preventing and treating diarrhea of piglets and preparation method thereof | 北京生泰尔科技股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-112174966-B | New method for preparing piroxicam hydrochloride | 重庆圣华曦药业股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-112174966-B | New method for preparing piroxicam hydrochloride | 重庆圣华曦药业股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-117903308-A | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies | 综合医院公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-115087488-A9 | Antibodies and fusion proteins that bind CCR8 and uses thereof | 震动疗法股份有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-117425495-A | Combination for the treatment of cancer | 赛达克斯制药股份有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-109476745-B | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies | 综合医院公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-112955179-A | Antagonistic anti-tumor necrosis factor receptor superfamily polypeptides | 综合医院公司 | 2021-06-11 | — | — | CN | disclosed |
| CN-111989107-A | Methods of treating cancer in pediatric patients | 阿瑞雅德制药公司 | 2020-11-24 | — | — | CN | disclosed |
| CN-106536518-B | Anthelmintic compounds | 勃林格殷格翰动物保健美国公司 | 2020-05-12 | — | — | CN | disclosed |
| CN-1151161-C | Nitrate salts of drugs | ƿ�ӻ��� | 2004-05-26 | — | — | CN | disclosed |
| US-6573252-B1 | Therapy and prevention of bony disorders; improved gastrointestinal tolerability | NICOX, S.A. (FR) | 2003-06-03 | — | — | US | disclosed |
| EP-1100805-B1 | MEDICINE NITRATE SALTS | NICOX SA (FR) | 2002-12-11 | — | — | EP | disclosed |
| CN-1310721-A | Medicine nitrate salts | NICOX SA (FR) | 2001-08-29 | — | — | CN | disclosed |
| EP-1100805-A1 | MEDICINE NITRATE SALTS | NICOX S.A. (FR) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006585-A1 | MEDICINE NITRATE SALTS | NICOX S.A. (FR) | 2000-02-10 | — | — | WO | disclosed |