Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.98 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.98 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.98 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroxicam SCHEMBL29352427 | 0.99 | PTGS1 (1.00) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL2680486 | 0.99 | PTGS1 (1.00) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL29396075 | 0.99 | PTGS1 (1.00) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL15741898 | 0.99 | PTGS1 (1.00) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL28536166 | 0.99 | PTGS1 (1.00) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL13462 | 0.99 | PTGS1 (1.00) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL5084571 | 0.98 | PTGS1 (0.98) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL6942519 | 0.98 | PTGS1 (0.98) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL8908556 | 0.98 | PTGS1 (0.98) | KDM4EMAPK1PTGS1USP2PTGS2 | |
| Piroxicam SCHEMBL27394226 | 0.98 | PTGS1 (0.98) | KDM4EMAPK1PTGS1USP2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0179430-B1 | AQUEOUS PHARMACEUTICAL FORMULATIONS OF PIROXICAM MONOHYDRATE | CHIESI FARMACEUTICI S.p.A. (IT) | 1991-08-28 | — | — | EP | claimed |
| US-4824841-A | ANTIINFLAMMATORY AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 1989-04-25 | — | — | US | claimed |
| EP-0179430-A2 | Aqueous pharmaceutical formulations of piroxicam monohydrate | CHIESI FARMACEUTICI S.p.A. (IT) | 1986-04-30 | — | — | EP | claimed |
| US-20230271142-A1 | METHODS OF PREPARING SOLID PARTICULATE MATERIALS | MICROPORE TECHNOLOGIES LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| EP-4188570-A2 | METHODS OF PREPARING SOLID PARTICULATE MATERIALS | Micropore Technologies Limited (GB) | 2023-06-07 | — | — | EP | disclosed |
| CN-116137813-A | Method for producing solid particulate material | 微孔技术有限公司 | 2023-05-19 | — | — | CN | disclosed |
| WO-2022023759-A2 | METHODS OF PREPARING SOLID PARTICULATE MATERIALS | MICROPORE TECHNOLOGIES LIMITED (GB) | 2022-02-03 | — | — | WO | disclosed |
| CN-110996907-A | Novel pharmaceutical compositions for basic or neutral low molecular weight compounds | 豪夫迈·罗氏有限公司 | 2020-04-10 | — | — | CN | disclosed |
| US-6726928-B2 | RAPID DISINTEGRATION; TASTE | R.P. SCHERER TECHNOLOGIES, INC. | 2004-04-27 | — | — | US | disclosed |
| JP-2003252764-A | PIROXICAM-CONTAINING AEROSOL COMPOSITION AND AEROSOL AGENT | TOYAMA CHEM CO LTD | 2003-09-10 | — | — | JP | disclosed |
| US-20020142038-A1 | Process for preparing solid dosage forms for unpalatable pharmaceuticals | CATALENT USA PACKAGING, LLC | 2002-10-03 | — | — | US | disclosed |
| WO-1999039713-A1 | PIROXICAM-CONTAINING HYDROALCOHOLIC GEL COMPOSITION | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 1999-08-12 | — | — | WO | disclosed |
| US-5196417-A | Water in oil emulsion | SAGITTA ARZNEIMITTEL GMBH (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0179430-B1 | AQUEOUS PHARMACEUTICAL FORMULATIONS OF PIROXICAM MONOHYDRATE | CHIESI FARMACEUTICI S.p.A. (IT) | 1991-08-28 | — | — | EP | disclosed |
| EP-0179430-B1 | AQUEOUS PHARMACEUTICAL FORMULATIONS OF PIROXICAM MONOHYDRATE | CHIESI FARMACEUTICI S.p.A. (IT) | 1991-08-28 | — | — | EP | disclosed |
| US-4824841-A | ANTIINFLAMMATORY AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 1989-04-25 | — | — | US | disclosed |
| US-4824841-A | ANTIINFLAMMATORY AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 1989-04-25 | — | — | US | disclosed |
| EP-0179430-A3 | AQUEOUS PHARMACEUTICAL FORMULATIONS OF PIROXICAM MONOHYDRATE | — | 1987-07-01 | — | — | EP | disclosed |
| EP-0179430-A2 | Aqueous pharmaceutical formulations of piroxicam monohydrate | CHIESI FARMACEUTICI S.p.A. (IT) | 1986-04-30 | — | — | EP | disclosed |
| EP-0179430-A2 | Aqueous pharmaceutical formulations of piroxicam monohydrate | CHIESI FARMACEUTICI S.p.A. (IT) | 1986-04-30 | — | — | EP | disclosed |