Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.98 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroxicam SCHEMBL13462 | 1.00 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL28536166 | 1.00 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL29396075 | 1.00 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL2680486 | 1.00 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL15741898 | 1.00 | PTGS1 (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6759456 | 0.99 | KDM4E (1.00) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL6942519 | 0.99 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL5084571 | 0.99 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL8908556 | 0.99 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 | |
| Piroxicam SCHEMBL27394226 | 0.99 | PTGS1 (0.98) | PTGS1KDM4EUSP2PTGS2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473291-B2 | Benzodiazepine compound, preparation method therefor, and use thereof in medicine | WEST CHINA HOSPITAL, SICHUAN UNIVERSITY (CN) | 2025-11-18 | — | — | US | claimed |
| US-12459857-B2 | Antimicrobial coating | Pilkington Technology Management Limited (GB) | 2025-11-04 | — | — | US | claimed |
| US-20250337007-A1 | POLYMER ELECTROLYTES AND BATTERIES WITH THE SAME | TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. (US) | 2025-10-30 | — | — | US | claimed |
| US-20250260049-A1 | FLUORINATED SULFONAMIDE COMPOUNDS FOR ENHANCING ION CONDUCTIVITY OF POLYMER ELECTROLYTES | TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. (US) | 2025-08-14 | — | — | US | claimed |
| EP-4574207-A2 | MEANS AND METHODS FOR TREATING COPPER-RELATED DISEASES | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2025-06-25 | — | — | EP | claimed |
| US-20250174717-A1 | POLYMER ELECTROLYTES AND BATTERIES WITH THE SAME | TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. (US) | 2025-05-29 | — | — | US | claimed |
| CN-120005927-A | Method for efficiently expressing streptococcus suis broad-spectrum antigen GDH | 山东省滨州畜牧兽医研究院 | 2025-05-16 | — | — | CN | claimed |
| CN-119875948-A | Cold-resistant motion nitromonas and application thereof in removal of ammonia nitrogen in sewage under low-temperature condition | 湖北华宸生态环境有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119876211-A | Construction method of donor fragment for gene knockout and knock-in | 杭州元腾生物工程股份有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119875978-A | Zymomonas mobilis chassis cell, construction method and application thereof | 湖北大学 | 2025-04-25 | — | — | CN | claimed |
| CN-114540218-A | Triton mobilis and application thereof | 自然资源部第三海洋研究所 | 2022-05-27 | — | — | CN | claimed |
| US-20220144694-A1 | ANTIMICROBIAL COATING | Pilkington Technology Management Limited (GB) | 2022-05-12 | — | — | US | claimed |
| CN-114438234-A | Korea type dynamic bending bacillus specificity PCR rapid detection kit | 中国科学技术大学 | 2022-05-06 | — | — | CN | claimed |
| CN-114245742-A | Treatment of T with PrevotellaH2-mediated disorders | 伊夫罗生物科学公司 | 2022-03-25 | — | — | CN | claimed |
| US-11278563-B2 | Rapid release pharmaceutical formulations containing algal cellulose | MIHRANYAN ALBERT (SE) | 2022-03-22 | — | — | US | claimed |
| US-20220080072-A1 | MATERIALS AND METHODS FOR DECONTAMINATING ANIMAL INTEGUMENT | TDA RESEARCH, INC. | 2022-03-17 | — | — | US | claimed |
| CN-114144511-A | Methods and compositions for anaerobic bacterial fermentation | 伊夫罗生物科学公司 | 2022-03-04 | — | — | CN | claimed |
| CN-114129737-A | Compositions and methods relating to particle removal | 纳米提克斯有限责任公司 | 2022-03-04 | — | — | CN | claimed |
| EP-3145960-B1 | ONE-STEP PROCESS FOR MAKING A POLYMER COMPOSITE COATING WITH HIGH BARRIER | AGENCY SCIENCE TECH & RES (SG) | 2022-02-23 | — | — | EP | claimed |
| US-20220049172-A1 | PROCESS FOR CATALYTIC PRODUCTION OF PROPANOL | NESTE OYJ (FI) | 2022-02-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220049172-A1 | PROCESS FOR CATALYTIC PRODUCTION OF PROPANOL | LIPA, GK, PNLIP | PTGS1 1047/4885PTGS2 735/4885KDM4E 4506/4885 |
| US-20250174717-A1 | POLYMER ELECTROLYTES AND BATTERIES WITH THE SAME | EPN1, SCO2, CORO1A | PTGS1 3364/4885PTGS2 3802/4885KDM4E 1606/4885 |
| US-12473291-B2 | Benzodiazepine compound, preparation method therefor, and use thereof in medicine | GABRA1, GABRA4, GABRR1 | PTGS1 778/4885PTGS2 1835/4885KDM4E 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.