Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845284 | 0.82 | PARP1 (0.40) | AKR1B1METAP1CYP26A1 | |
| SCHEMBL7835917 | 0.82 | LDHA (0.37) | CA2AKR1B1ALDH1A1CYP19A1METAP1 | |
| SCHEMBL7844888 | 0.80 | JAK1 (0.36) | CA2AKR1B1ALDH1A1 | |
| SCHEMBL7845195 | 0.80 | MAPT (0.44) | KDM4EALDH1A1 | |
| SCHEMBL7845549 | 0.78 | FFAR1 (0.40) | CA2AKR1B1 | |
| SCHEMBL6972986 | 0.73 | METAP1 (0.54) | CYP19A1METAP1 | |
| SCHEMBL8091023 | 0.72 | CYP4F2 (0.48) | KDM4EALDH1A1 | |
| SCHEMBL28770218 | 0.72 | CASP1 (0.51) | CA2AKR1B1 | |
| SCHEMBL2010435 | 0.71 | HTR2A (0.42) | — | |
| SCHEMBL8628473 | 0.71 | AKR1C3 (0.34) | KDM4EALDH1A1METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |