Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | MMP13 | P45452 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27397793 | 0.90 | MMP9 (0.56) | HPGDMMP13TP53MMP9MAPT | |
| SCHEMBL23542291 | 0.89 | MAPT (0.59) | HPGDMMP13CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23542320 | 0.88 | MMP9 (0.55) | HPGDMMP13CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23542293 | 0.85 | TP53 (0.52) | HPGDMMP13TP53MMP9MAPT | |
| SCHEMBL23542301 | 0.84 | MMP9 (0.64) | HPGDMMP13CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27397785 | 0.83 | HPGD (0.54) | HPGDMMP13CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23542298 | 0.83 | MAPT (0.61) | HPGDMMP13CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23542306 | 0.82 | TP53 (0.55) | HPGDMMP13CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27397805 | 0.81 | MMP9 (0.52) | HPGDMMP13TP53MMP9MAPT | |
| SCHEMBL27397788 | 0.81 | MMP13 (0.52) | HPGDMMP13CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018003-B2 | Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2024-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12018003-B2 | Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors | MMP9, MMP7, MMP11 | HPGD 259/4885MMP13 33/4885CYP1A2 2212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.