Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27398651 | 0.88 | LCK (0.37) | DHODHLCKBTKMKNK1MKNK2 | |
| SCHEMBL27398649 | 0.85 | MKNK1 (0.35) | LCKBTKMKNK1MKNK2PRMT5 | |
| SCHEMBL27399603 | 0.84 | MKNK1 (0.40) | DHODHLCKBTKMKNK1MKNK2 | |
| SCHEMBL27400738 | 0.84 | LCK (0.37) | LCKBTKMKNK1MKNK2PRMT5 | |
| SCHEMBL27399014 | 0.83 | LCK (0.51) | DHODHLCKBTKMKNK1MKNK2 | |
| SCHEMBL27399247 | 0.83 | MKNK1 (0.50) | DHODHLCKBTKMKNK1MKNK2 | |
| SCHEMBL27400120 | 0.80 | PRMT5 (0.39) | DHODHMKNK1MKNK2PRMT5LIMK1 | |
| SCHEMBL27400004 | 0.80 | IKBKB (0.35) | LCKBTKMKNK1MKNK2PRMT5 | |
| SCHEMBL27399583 | 0.80 | MKNK1 (0.40) | DHODHLCKBTKMKNK1MKNK2 | |
| SCHEMBL27399933 | 0.80 | PRMT5 (0.41) | DHODHLCKBTKMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |