Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27399247 | 0.87 | MKNK1 (0.50) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27399600 | 0.86 | IRAK4 (0.35) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27399014 | 0.85 | LCK (0.51) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27399330 | 0.84 | DHODH (0.39) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27399917 | 0.84 | DHODH (0.34) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27398651 | 0.83 | LCK (0.37) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27399583 | 0.82 | MKNK1 (0.40) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27399933 | 0.81 | PRMT5 (0.41) | MKNK1MKNK2LCKBTKLIMK1 | |
| SCHEMBL27400006 | 0.80 | DHODH (0.40) | LCKBTKLIMK1DHODHIKBKB | |
| SCHEMBL27400004 | 0.80 | IKBKB (0.35) | MKNK1MKNK2LCKBTKLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |