Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 7/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.32 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.32 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.32 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27398651 | 0.81 | LCK (0.37) | IKBKBPARP1LIMK1LCKBTK | |
| SCHEMBL27399014 | 0.81 | LCK (0.51) | IKBKBPARP1LIMK1LCKBTK | |
| SCHEMBL27399330 | 0.80 | DHODH (0.39) | PARP1LIMK1LCKBTKMKNK1 | |
| SCHEMBL27399603 | 0.80 | MKNK1 (0.40) | IKBKBPARP1LIMK1LCKBTK | |
| SCHEMBL27399597 | 0.78 | LIMK1 (0.37) | IKBKBPARP1LIMK1LCKBTK | |
| SCHEMBL27398649 | 0.78 | MKNK1 (0.35) | IKBKBLCKBTKMKNK1MKNK2 | |
| SCHEMBL27400006 | 0.78 | DHODH (0.40) | IKBKBLIMK1LCKBTK | |
| SCHEMBL27400738 | 0.78 | LCK (0.37) | PARP1LIMK1LCKBTKMKNK1 | |
| SCHEMBL27399247 | 0.77 | MKNK1 (0.50) | IKBKBPARP1LIMK1LCKBTK | |
| SCHEMBL27399933 | 0.77 | PRMT5 (0.41) | IKBKBPARP1LIMK1LCKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |