Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 9/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30836039 | 1.00 | TEAD1 (0.53) | TEAD1DCUN1D1EGFRPOLBLMNA | |
| SCHEMBL30835946 | 0.93 | TEAD1 (0.56) | TEAD1DCUN1D1EGFRPOLBLMNA | |
| SCHEMBL27399837 | 0.93 | TEAD1 (0.56) | TEAD1DCUN1D1EGFRPOLBLMNA | |
| SCHEMBL31556577 | 0.93 | TEAD1 (0.56) | TEAD1DCUN1D1EGFRPOLBLMNA | |
| SCHEMBL27399893 | 0.93 | TEAD1 (0.56) | TEAD1DCUN1D1EGFRPOLBLMNA | |
| SCHEMBL27400097 | 0.87 | TEAD1 (0.52) | TEAD1DCUN1D1EGFRPOLBITK | |
| SCHEMBL27400112 | 0.86 | TEAD1 (0.56) | TEAD1DCUN1D1EGFRTEAD3 | |
| SCHEMBL30835997 | 0.80 | GPR119 (0.47) | POLB | |
| SCHEMBL30835988 | 0.79 | TEAD1 (0.54) | TEAD1EGFRTEAD3ITK | |
| SCHEMBL27399668 | 0.79 | TEAD1 (0.54) | TEAD1EGFRTEAD3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059317-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | BRIDGENE BIOSCIENCES, INC. (US) | 2024-03-21 | — | — | WO | disclosed |