Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15151257 | 1.00 | TSHR (0.41) | TSHRCA2L3MBTL1POLBHCRTR2 | |
| SCHEMBL27427939 | 1.00 | TSHR (0.41) | TSHRCA2L3MBTL1POLBHCRTR2 | |
| SCHEMBL28912789 | 0.87 | CA2 (0.37) | CA2L3MBTL1HCRTR2HCRTR1CA1 | |
| SCHEMBL5597174 | 0.85 | L3MBTL1 (0.36) | CA2L3MBTL1HCRTR2HCRTR1TMEM97 | |
| SCHEMBL10374015 | 0.83 | CA2 (0.35) | TSHRCA2L3MBTL1HCRTR2HCRTR1 | |
| SCHEMBL1876643 | 0.82 | TSHR (0.38) | TSHRCA2 | |
| SCHEMBL10965421 | 0.82 | L3MBTL1 (0.37) | CA2L3MBTL1HCRTR2HCRTR1CA1 | |
| SCHEMBL24082907 | 0.80 | CA2 (0.37) | CA2L3MBTL1HCRTR2HCRTR1TMEM97 | |
| SCHEMBL10716770 | 0.80 | ALDH1A1 (0.41) | CA2L3MBTL1ALDH1A1 | |
| SCHEMBL3683016 | 0.80 | MAPT (0.33) | CA2L3MBTL1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1222519-C | Reverse hydroxamate inhibitors of matrix metalloproteinases | ABBOTT LAB (US) | 2005-10-12 | — | — | CN | disclosed |
| CN-1339032-A | Reverse hydroxamate inhibitors of matrix metalloproteinases | ABBOTT LAB (US) | 2002-03-06 | — | — | CN | disclosed |
| CN-1085546-A | Aminediol protease inhibitors | SQUIBB & SONS INC (US) | 1994-04-20 | — | — | CN | disclosed |