Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437389 | 0.90 | GRM4 (0.41) | MAPTALDH1A1LMNASMN1; SMN2FAAH | |
| SCHEMBL2435834 | 0.85 | PPIA (0.48) | BRAFHTTKMT2AMEN1MAPT | |
| SCHEMBL273501 | 0.83 | TRPV1 (0.52) | GRIN2BHTTKMT2AMEN1NPSR1 | |
| SCHEMBL273466 | 0.79 | KDR (0.54) | BRAFFGFR1FGFR2FGFR3CDK2 | |
| SCHEMBL3790500 | 0.78 | KDR (0.64) | BRAFMAPK14TRPV1KDR | |
| SCHEMBL2708220 | 0.76 | MAOB (0.53) | NPSR1ALDH1A1SMN1; SMN2FAAH | |
| SCHEMBL274235 | 0.76 | KDR (0.51) | BRAFFGFR1FGFR2FGFR3CDK2 | |
| SCHEMBL273474 | 0.75 | TRPV1 (0.57) | BRAFTRPV1KDR | |
| SCHEMBL2434309 | 0.72 | KDR (0.50) | BRAFKDR | |
| SCHEMBL2437298 | 0.72 | AR (0.41) | BRAFMAPTGRM4TRPV1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133886-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2012-03-13 | — | — | US | disclosed |
| EP-2371822-A1 | Heterobicyclic carboxamides as inhibitors for kinases | Novartis AG (CH) | 2011-10-05 | — | — | EP | disclosed |