Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 2/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273501 | 0.88 | TRPV1 (0.52) | TRPV1MAPTKDR | |
| SCHEMBL2437389 | 0.83 | GRM4 (0.41) | ARGRM4CDK8MAPTRORC | |
| SCHEMBL2435262 | 0.81 | TRPV1 (0.48) | TRPV1TP53MAPT | |
| SCHEMBL2434309 | 0.79 | KDR (0.50) | BRAFKDR | |
| SCHEMBL2435966 | 0.78 | KDR (0.57) | CDK8BRAFKDR | |
| SCHEMBL2434370 | 0.77 | KDR (0.59) | CDK8BRAFKDR | |
| SCHEMBL2434130 | 0.77 | KDR (0.45) | CDK8RORCBRAFKDR | |
| SCHEMBL274088 | 0.72 | GRIN2B (0.47) | GRM4TRPV1MAPTBRAFKDR | |
| SCHEMBL18615565 | 0.72 | KDR (0.47) | CDK8THRBTP53POLBMAPT | |
| SCHEMBL282336 | 0.70 | AR (0.62) | ARGRM4CDK8TRPV1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |