Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437298 | 0.88 | AR (0.41) | TRPV1KDRMAPT | |
| SCHEMBL274088 | 0.83 | GRIN2B (0.47) | TRPV1KDRMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL2435262 | 0.81 | TRPV1 (0.48) | TRPV1MAPTNPSR1SMN1; SMN2GRIN2B | |
| SCHEMBL273466 | 0.80 | KDR (0.54) | KDRMEN1KMT2A | |
| SCHEMBL274235 | 0.77 | KDR (0.51) | KDRMEN1KMT2A | |
| SCHEMBL7558694 | 0.72 | KDR (0.59) | KDRMAPTPDK1NPSR1SMN1; SMN2 | |
| SCHEMBL2434309 | 0.72 | KDR (0.50) | KDR | |
| SCHEMBL18615701 | 0.72 | KDR (0.50) | KDRMAPTHTT | |
| SCHEMBL2437389 | 0.72 | GRM4 (0.41) | MAPTPDK1SMN1; SMN2 | |
| SCHEMBL281864 | 0.71 | KDR (0.85) | TRPV1KDRPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133886-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2012-03-13 | — | — | US | disclosed |
| EP-2371822-A1 | Heterobicyclic carboxamides as inhibitors for kinases | Novartis AG (CH) | 2011-10-05 | — | — | EP | disclosed |