Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 2/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274088 | 0.90 | GRIN2B (0.47) | GRM4FAAHLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2435834 | 0.85 | PPIA (0.48) | PDK1PDK2PDK3PDK4FAAH | |
| SCHEMBL2437298 | 0.83 | AR (0.41) | GRM4UBE2MDCUN1D1RORCAR | |
| SCHEMBL2434309 | 0.78 | KDR (0.50) | — | |
| SCHEMBL2435966 | 0.78 | KDR (0.57) | CDK8 | |
| SCHEMBL2708220 | 0.77 | MAOB (0.53) | PDK1PDK2PDK3PDK4FAAH | |
| SCHEMBL2434370 | 0.77 | KDR (0.59) | CDK8 | |
| SCHEMBL2432234 | 0.74 | KDR (0.50) | GRM4ARCTSVCTSLCDK8 | |
| SCHEMBL18615565 | 0.70 | KDR (0.47) | CDK8LMNAMAPT | |
| SCHEMBL273466 | 0.70 | KDR (0.54) | HTR2AHTR2CHTR2BMAOACDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |