Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28360387 | 0.83 | WDR5 (0.41) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL29356413 | 0.81 | KDM4E (0.58) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL9488962 | 0.81 | HTT (0.54) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL5675873 | 0.81 | KDM4E (0.54) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL453345 | 0.81 | KDM4E (0.58) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL6621295 | 0.79 | HPGD (0.46) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL30060732 | 0.79 | NCEH1 (0.46) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL4752091 | 0.78 | KDM4E (0.54) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL455028 | 0.78 | MAPT (0.53) | HTTMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL2761576 | 0.78 | WDR5 (0.56) | HTTMAPTKDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1101806-C | Novel gem-difluoro derivatives of phenylacetemide- and phenylacetic acid and their pharmaceutical uses | FUNDACAO OSWALDO CRUZ (BR) | 2003-02-19 | — | — | CN | disclosed |
| CN-1159443-A | Novel gem-difluoro derivatives of phenylacetemide- and phenylacetic acid and their pharmaceutical uses | FUNDACAO OSWALDO CRUZ (BR) | 1997-09-17 | — | — | CN | disclosed |