Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13128916 | 0.81 | CA2 (0.47) | CA2GAB1PKMMEN1KMT2A | |
| SCHEMBL2740946 | 0.77 | CRHBP (0.59) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740959 | 0.77 | CRHBP (0.51) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740961 | 0.77 | MEN1 (0.51) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740945 | 0.74 | CRHBP (0.51) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740960 | 0.72 | CRHBP (0.46) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740998 | 0.72 | CRHBP (0.60) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740966 | 0.71 | CRHBP (0.57) | CRHBPCRHR2NHERF1MCL1PKM | |
| SCHEMBL2740971 | 0.70 | CRHBP (0.49) | CRHBPCRHR2NHERF1MCL1MEN1 | |
| SCHEMBL15647549 | 0.69 | NFKBIA (0.61) | CRHBPCRHR2NHERF1MCL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |