Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.57 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740946 | 0.92 | CRHBP (0.59) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL2740965 | 0.88 | CRHBP (0.53) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL2740967 | 0.86 | KMT2A (0.52) | CRHBPCRHR2ALDH1A1MCL1HPGD | |
| SCHEMBL13128923 | 0.85 | ALDH1A1 (0.51) | ALDH1A1HPGDL3MBTL1MEN1KMT2A | |
| SCHEMBL2740998 | 0.80 | CRHBP (0.60) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL15647549 | 0.79 | NFKBIA (0.61) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL2740959 | 0.77 | CRHBP (0.51) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL2740961 | 0.77 | MEN1 (0.51) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL2741012 | 0.77 | CRHBP (0.53) | CRHBPCRHR2NHERF1ALDH1A1MCL1 | |
| SCHEMBL1970882 | 0.77 | CRHBP (0.72) | CRHBPCRHR2HPGDL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |