Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27393362 | 0.92 | P2RX3 (0.37) | TDP1HTR6POLBMAPTTHRB | |
| SCHEMBL27412267 | 0.85 | TDP1 (0.36) | TDP1KMT2APTGS1PTGS2 | |
| SCHEMBL27391539 | 0.85 | HTR6 (0.36) | APLNRHTR6POLBTHRBKDM4E | |
| SCHEMBL27390607 | 0.85 | MMP1 (0.34) | TDP1HTR6THRBKDM4EMMP1 | |
| SCHEMBL27410682 | 0.82 | TDP1 (0.37) | TDP1POLBMAPTTHRBTP53 | |
| SCHEMBL27462484 | 0.82 | HDAC1 (0.35) | TDP1APLNRPTGS1PTGS2 | |
| SCHEMBL27409969 | 0.82 | TDP1 (0.35) | TDP1APLNRHTR6MAPTPTGS1 | |
| SCHEMBL6967282 | 0.82 | TDP1 (0.32) | TDP1POLBMEN1KMT2AMAPT | |
| SCHEMBL27389952 | 0.82 | P2RX3 (0.35) | TDP1KMT2AMAPTTP53NAMPT | |
| SCHEMBL27397423 | 0.81 | TDP1 (0.37) | TDP1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1093535-C | Imidazole derivative | SHIONOGI & CO (JP) | 2002-10-30 | — | — | CN | disclosed |
| CN-1158609-A | Imidazole derivative | SHIONOGI & CO (JP) | 1997-09-03 | — | — | CN | disclosed |