Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27422296 | 0.96 | KDM4E (0.36) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL23962032 | 0.92 | TSHR (0.38) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL19387290 | 0.89 | KDM4E (0.48) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL27422338 | 0.88 | GRM7 (0.43) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL23961925 | 0.88 | TSHR (0.38) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL20758286 | 0.87 | ALDH1A1 (0.39) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL23961987 | 0.87 | LMNA (0.35) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 | |
| SCHEMBL20223535 | 0.87 | TP53 (0.33) | SMN1; SMN2ALDH1A1CYP2C9CYP2C19MEN1 | |
| SCHEMBL22512575 | 0.87 | HSD17B3 (0.48) | KDM4EALDH1A1CYP2C9HSD17B3LMNA | |
| SCHEMBL23192062 | 0.86 | NOTUM (0.36) | KDM4ESMN1; SMN2HTTALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240218011-A1 | GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF | FIREFLY BIO, INC. | 2024-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240218011-A1 | GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF | NR3C1, NR3C2, MC2R | KDM4E 4391/4885SMN1; SMN2 3733/4885HTT 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.