SCHEMBL27424699

SCHEMBL27424699

COC(=O)C(=Cc1ccc(OC)c(-c2ccccc2)c1)CC(=O)O

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.44
CTSA P10619 1/20 0.43
PTGDR2 Q9Y5Y4 5/20 0.42
MAPT P10636 4/20 0.42
GAA P10253 3/20 0.42
KDM4E B2RXH2 3/20 0.42
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
ALDH1A1 P00352 3/20 0.40
PKM P14618 1/20 0.40
LTB4R Q15722 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
NPC1 O15118 1/20 0.39
AKR1C3 P42330 1/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6132092 0.85 GAA (0.55) MAPTGAAKDM4EALDH1A1PKM
SCHEMBL6132093 0.85 GAA (0.55) MAPTGAAKDM4EALDH1A1PKM
SCHEMBL27725356 0.81 RECQL (0.58) RECQLGAALMNAHTT
SCHEMBL1915837 0.79 RECQL (0.69) RECQLMAPTAKR1C3
SCHEMBL1915838 0.79 RECQL (0.69) RECQLMAPTAKR1C3
SCHEMBL1915834 0.79 RECQL (0.69) RECQLMAPTAKR1C3
SCHEMBL4032454 0.79 PTGS2 (0.56) RECQLMAPTAKR1C3
SCHEMBL4032452 0.79 PTGS2 (0.56) RECQLMAPTAKR1C3
SCHEMBL9023562 0.76 ALDH1A1 (0.55) RECQLMAPTKDM4EALDH1A1LMNA
Benzene SCHEMBL27424700 0.76 ALDH1A1 (0.55) RECQLMAPTKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1129605-C Modified aminoacids, pharmaceuticals containing these compounds and method for their prodn. THOMAE GMBH DR K (DE) 2003-12-03 CN disclosed
CN-1230196-A Modified aminoacids, pharmaceuticals containing these compounds and method for their prodn. THOMAE GMBH DR K (DE) 1999-09-29 CN disclosed