Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.54 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.54 |
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.48 |
| ▸ | GABRE | P78334 | 2/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12118145 | 1.00 | DPP4 (0.54) | DPP4DPP8DPP9GABRPGABRD | |
| SCHEMBL21724629 | 0.90 | DPP4 (0.51) | DPP4DPP8DPP9GABRPGABRD | |
| SCHEMBL21724631 | 0.90 | DPP4 (0.51) | DPP4DPP8DPP9GABRPGABRD | |
| Hydrochloric Acid SCHEMBL21724239 | 0.88 | DPP4 (0.50) | DPP4DPP8DPP9GABRPGABRD | |
| Hydrochloric Acid SCHEMBL21724238 | 0.88 | DPP4 (0.50) | DPP4DPP8DPP9GABRPGABRD | |
| SCHEMBL10162444 | 0.86 | DPP4 (0.63) | DPP4DPP8DPP9GABRPGABRD | |
| SCHEMBL27182875 | 0.86 | DPP4 (0.42) | DPP4DPP8DPP9GABRPGABRD | |
| SCHEMBL27182806 | 0.86 | DPP9 (0.42) | DPP4DPP8DPP9GRIK1SLC1A3 | |
| SCHEMBL11668477 | 0.81 | DPP4 (0.41) | DPP4DPP8DPP9 | |
| SCHEMBL5053928 | 0.81 | DPP4 (0.41) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9877923-B2 | Process for preparing therapeutic nanoparticles | PFIZER INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-9872913-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | PFIZER INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170266187-A1 | Pemetrexed Polymeric Nanoparticles And Methods Of Making And Using Same | PFIZER INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170209374-A1 | METHODS OF CONTROLLING THE MORPHOLOGY OF POLYMERIC NANOPARTICLES | PFIZER (US) | 2017-07-27 | — | — | US | disclosed |
| US-9579386-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | PFIZER INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160367481-A1 | CANCER CELL TARGETING USING NANOPARTICLES | PFIZER INC. | 2016-12-22 | — | — | US | disclosed |
| US-20160338959-A1 | DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME | PFIZER INC. | 2016-11-24 | — | — | US | disclosed |
| US-9393310-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND THERAPEUTICS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9375481-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND THERAPEUTICS, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150147339-A1 | BIOMARKERS FOR PSMA TARGETED THERAPY FOR PROSTATE CANCER | PSMA DEVELOPMENT COMPANY, LLC (US) | 2015-05-28 | — | — | US | disclosed |
| US-20130115192-A1 | Methods for the Preparation of Targeting Agent Functionalized Diblock Copolymers for Use in Fabrication of Therapeutic Targeted Nanoparticles | BIND BIOSCIENCES, INC (US) | 2013-05-09 | — | — | US | disclosed |
| US-8318208-B1 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND BIOSCIENCES, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120288541-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120276162-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | PFIZER INC. | 2012-11-01 | — | — | US | disclosed |
| US-8293276-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND BIOSCIENCES, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8273363-B2 | Cancer cell targeting using nanoparticles | BIND BIOSCIENCES, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8236330-B2 | Cancer cell targeting using nanoparticles | BIND BIOSCIENCES, INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-20120004293-A1 | Cancer Cell Targeting Using Nanoparticles | PFIZER INC. | 2012-01-05 | — | — | US | disclosed |
| US-20110274759-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | PFIZER INC. | 2011-11-10 | — | — | US | disclosed |
| US-20110224288-A1 | Cancer Cell Targeting Using Nanoparticles | PFIZER INC. | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120276162-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | CD47, LPXN, CD44 | DPP4 3241/4885DPP8 3561/4885DPP9 2650/4885 |
| US-20110274759-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | LDHA, LDHB, LPXN | DPP4 3513/4885DPP8 3407/4885DPP9 2671/4885 |
| US-20160338959-A1 | DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME | LDHA, LDHB, LPXN | DPP4 3513/4885DPP8 3407/4885DPP9 2671/4885 |
| US-20110224288-A1 | Cancer Cell Targeting Using Nanoparticles | CD47, EPCAM, CD44 | DPP4 4142/4885DPP8 4083/4885DPP9 3214/4885 |
| US-20130115192-A1 | Methods for the Preparation of Targeting Agent Functionalized Diblock Copolymers for Use in Fabrication of Therapeutic Targeted Nanoparticles | GNE, PAM, EPHA2 | DPP4 4099/4885DPP8 2922/4885DPP9 3508/4885 |
| US-20120288541-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | CD47, LPXN, CD44 | DPP4 3241/4885DPP8 3561/4885DPP9 2650/4885 |
| US-20170209374-A1 | METHODS OF CONTROLLING THE MORPHOLOGY OF POLYMERIC NANOPARTICLES | CLTB, NCL, CLTA | DPP4 3975/4885DPP8 3814/4885DPP9 3720/4885 |
| US-20170266187-A1 | Pemetrexed Polymeric Nanoparticles And Methods Of Making And Using Same | MTHFD1, TYMP, FPGS | DPP4 4182/4885DPP8 4201/4885DPP9 3430/4885 |
| US-20120004293-A1 | Cancer Cell Targeting Using Nanoparticles | CD47, EPCAM, CD44 | DPP4 4142/4885DPP8 4083/4885DPP9 3214/4885 |
| US-20160367481-A1 | CANCER CELL TARGETING USING NANOPARTICLES | CD47, EPCAM, CD44 | DPP4 4142/4885DPP8 4083/4885DPP9 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.