Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437553 | 0.83 | GSK3B (0.54) | GSK3BMEN1KMT2AATRADRA1A | |
| SCHEMBL2744244 | 0.76 | TUBB4A (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2744245 | 0.75 | TUBB4A (0.50) | DRD1DRD2HTR2ATUBB4ATUBB | |
| Stegane SCHEMBL5014561 | 0.73 | TUBB4A (0.53) | GSK3BMEN1KMT2AATRADRA1A | |
| Picrostegane SCHEMBL14097820 | 0.73 | TUBB4A (0.53) | GSK3BMEN1KMT2AATRADRA1A | |
| SCHEMBL6429218 | 0.72 | TUBB4A (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2743793 | 0.70 | CYP3A4 (0.44) | GSK3BMEN1KMT2AATRPOLB | |
| SCHEMBL2743641 | 0.70 | ATM (0.49) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3573727 | 0.70 | TUBB4A (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2743594 | 0.70 | TUBB4A (0.48) | GSK3BKMT2AHTR2BTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178578-B2 | Chemical compounds | THE UNIVERSITY OF MANCHESTER (GB) | 2012-05-15 | — | — | US | claimed |
| US-20100016261-A1 | CHEMICAL COMPOUNDS | THE UNIVERSITY OF MANCHESTER (GB) | 2010-01-21 | — | — | US | claimed |
| US-8178578-B2 | Chemical compounds | THE UNIVERSITY OF MANCHESTER (GB) | 2012-05-15 | — | — | US | disclosed |
| US-8178578-B2 | Chemical compounds | THE UNIVERSITY OF MANCHESTER (GB) | 2012-05-15 | — | — | US | disclosed |
| US-8178578-B2 | Chemical compounds | THE UNIVERSITY OF MANCHESTER (GB) | 2012-05-15 | — | — | US | disclosed |
| US-20100016261-A1 | CHEMICAL COMPOUNDS | THE UNIVERSITY OF MANCHESTER (GB) | 2010-01-21 | — | — | US | disclosed |
| US-20100016261-A1 | CHEMICAL COMPOUNDS | THE UNIVERSITY OF MANCHESTER (GB) | 2010-01-21 | — | — | US | disclosed |
| US-20100016261-A1 | CHEMICAL COMPOUNDS | THE UNIVERSITY OF MANCHESTER (GB) | 2010-01-21 | — | — | US | disclosed |
| WO-2008075048-A2 | POLYALKYLOXYDIBENZ ( C, E) OXEPINE DERIVATIVES AS MEDICAMENTS | THE UNIVERSITY OF MANCHESTER (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016261-A1 | CHEMICAL COMPOUNDS | CYP11B2, MPO, PIGO | GSK3B 2541/4885MEN1 907/4885KMT2A 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.