Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744850 | 0.97 | LMNA (0.47) | LMNASMN1; SMN2PARP1KMT2AHTR7 | |
| SCHEMBL11917581 | 0.89 | KMT2A (0.38) | PARP1KMT2APPARGPPARAKDM4E | |
| SCHEMBL11917587 | 0.86 | PPARG (0.40) | PARP1KMT2APPARGPPARAKDM4E | |
| SCHEMBL2743709 | 0.84 | SGPL1 (0.37) | LMNASMN1; SMN2PARP1KMT2AMAPT | |
| SCHEMBL2744108 | 0.84 | SGPL1 (0.37) | LMNASMN1; SMN2PARP1KMT2AMAPT | |
| SCHEMBL2743711 | 0.84 | SGPL1 (0.37) | LMNASMN1; SMN2PARP1KMT2AMAPT | |
| SCHEMBL2744304 | 0.83 | MCHR1 (0.34) | LMNASMN1; SMN2PARP1ALDH1A1KDM4E | |
| SCHEMBL2743818 | 0.80 | LMNA (0.48) | LMNASMN1; SMN2PARP1KMT2AHTR7 | |
| SCHEMBL4398116 | 0.80 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2KMT2APPARGPPARD | |
| SCHEMBL2743816 | 0.79 | LMNA (0.45) | LMNASMN1; SMN2PARP1KMT2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202782-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2012-08-09 | — | — | US | claimed |
| EP-2167498-B1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-09-15 | — | — | EP | claimed |
| US-20100184748-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-07-22 | — | — | US | claimed |
| US-20120202782-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2012-08-09 | — | — | US | disclosed |
| US-20120202782-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2012-08-09 | — | — | US | disclosed |
| US-8178526-B2 | Compounds and compositions as ITPKb inhibitors | IRM LLC (BM) | 2012-05-15 | — | — | US | disclosed |
| US-8178526-B2 | Compounds and compositions as ITPKb inhibitors | IRM LLC (BM) | 2012-05-15 | — | — | US | disclosed |
| US-8178526-B2 | Compounds and compositions as ITPKb inhibitors | IRM LLC (BM) | 2012-05-15 | — | — | US | disclosed |
| EP-2167498-B1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-09-15 | — | — | EP | disclosed |
| EP-2167498-B1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-09-15 | — | — | EP | disclosed |
| US-20100184748-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
| US-20100184748-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
| US-20100184748-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
| EP-2167498-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008157210-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157210-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202782-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IP6K1, IP6K2, IP6K3 | LMNA 2876/4885SMN1; SMN2 3491/4885PARP1 2073/4885 |
| US-20100184748-A1 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IP6K1, IP6K3, IP6K2 | LMNA 3015/4885SMN1; SMN2 3869/4885PARP1 2302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.