Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dimpylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.87 |
| ▸ | TSHR | P16473 | 4/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.87 |
| ▸ | TP53 | P04637 | 1/20 | 0.87 |
| ▸ | ACHE | P22303 | 1/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimpylate SCHEMBL9812731 | 0.95 | ALDH1A1 (0.83) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL9812732 | 0.95 | ALDH1A1 (0.92) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL6118696 | 0.93 | ALDH1A1 (1.00) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL17453 | 0.93 | ALDH1A1 (1.00) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL28276693 | 0.92 | ALDH1A1 (0.87) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL3756703 | 0.92 | ALDH1A1 (0.87) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL6135123 | 0.92 | ALDH1A1 (0.92) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL28706929 | 0.92 | ALDH1A1 (0.92) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL4747660 | 0.92 | ALDH1A1 (0.92) | ALDH1A1TSHRCYP3A4HSD17B10TP53 | |
| Dimpylate SCHEMBL6753267 | 0.92 | ALDH1A1 (0.97) | ALDH1A1TSHRCYP3A4HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118388727-A | Preparation method of magnetic covalent organic framework material and application of magnetic covalent organic framework material in extraction of organic phosphorus | 中国政法大学 | 2024-07-26 | — | — | CN | disclosed |
| CN-118044519-A | Molecules having pesticidal utility, and intermediates, compositions and methods related thereto | 科迪华农业科技有限责任公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-116966875-A | Preparation method and application of carbon nanomaterial for detecting propamocarb in reverse chromatographic column | 中国农业科学院郑州果树研究所 | 2023-10-31 | — | — | CN | disclosed |
| CN-116046957-A | Endocrine disruptors for screening for risk of focal segmental glomerulosclerosis | 南京医科大学附属逸夫医院 | 2023-05-02 | — | — | CN | disclosed |
| CN-112292035-A | Water-dispersible pesticide composition | 日本化药株式会社 | 2021-01-29 | — | — | CN | disclosed |
| CN-1099235-C | Insecticidal and miticidal compositions | AMERICAN CYANAMID CO (US) | 2003-01-22 | — | — | CN | disclosed |
| CN-1241115-A | Insecticidal and miticidal compositions | AMERICAN CYANAMID CO (US) | 2000-01-12 | — | — | CN | disclosed |