Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17538707 | 0.88 | ALDH1A1 (0.67) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL2743926 | 0.85 | ALDH1A1 (0.61) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL532027 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL15332644 | 0.84 | ALDH1A1 (0.70) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL2557321 | 0.84 | ALDH1A1 (0.81) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL7683038 | 0.82 | SRC (0.47) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL4262680 | 0.82 | FDPS (0.57) | ALDH1A1CYP1A2APPLMNAFDPS | |
| SCHEMBL2558197 | 0.82 | ALDH1A1 (0.71) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL4262685 | 0.82 | FDPS (0.57) | ALDH1A1CYP1A2APPLMNAFDPS | |
| SCHEMBL2284391 | 0.81 | ALDH1A1 (0.74) | ALDH1A1CYP1A2CYP2C19SMN1; SMN2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178727-B2 | Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer | NATIONAL UNIVERSITY CORPORATION TOHOKU UNIVERSITY (JP) | 2012-05-15 | — | — | US | disclosed |
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | SHIBATA, HIROYUKI (JP) | 2010-06-17 | — | — | US | disclosed |
| US-7202247-B2 | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders | ATHEROGENICS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20030232877-A1 | 1,3-Bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders | CRABTREE ACQUISITION CO, LLC | 2003-12-18 | — | — | US | disclosed |
| WO-2003053359-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPYN-1-ONES AND THEIR USE TO TREAT DISORDERS | ATHEROGENICS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | MYC, CCNE2, CCNE1 | ALDH1A1 614/4885MAPK1 546/4885CYP1A2 1717/4885 |
| US-20030232877-A1 | 1,3-Bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders | SLC10A1, PKD1, ABCB11 | ALDH1A1 111/4885MAPK1 1497/4885CYP1A2 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.