Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 10/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451116 | 0.86 | RAB9A (0.77) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27451505 | 0.81 | NPC1 (0.59) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL31050189 | 0.81 | NPC1 (0.59) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL31050188 | 0.81 | NPC1 (0.59) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27451123 | 0.80 | RAB9A (0.68) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27852729 | 0.80 | RAB9A (0.52) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27452146 | 0.77 | NPC1 (0.55) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27451276 | 0.77 | RAB9A (0.54) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27452585 | 0.75 | RAB9A (0.58) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL27451351 | 0.74 | RAB9A (0.68) | NPC1RAB9AKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145662-A1 | 2-SUBSTITUTED THIAZOLE AND BENZOTHIAZOLE COMPOSITIONS AND METHODS AS DUX4 INHIBITORS | ALTAY THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |