Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 5/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SORD | Q00796 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27457780 | 0.83 | PTGER4 (0.45) | ROCK2ACACBPTGER4SORDSCN10A | |
| SCHEMBL31706076 | 0.83 | ROCK2 (0.41) | ROCK2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL31706298 | 0.81 | HRH3 (0.52) | HSD17B10SORDHRH4HRH3 | |
| SCHEMBL31706338 | 0.81 | HRH3 (0.52) | HSD17B10SORDHRH4HRH3 | |
| SCHEMBL31706327 | 0.79 | ROCK2 (0.39) | ROCK2PTGER4CYP3A4CYP2D6TSHR | |
| SCHEMBL31704767 | 0.77 | CKS1B (0.49) | TSHRHSD17B10SORDHRH4HRH3 | |
| SCHEMBL20746083 | 0.76 | CRBN (0.59) | ROCK2ACACBCYP3A4CYP2D6SCN10A | |
| SCHEMBL31705550 | 0.76 | CKS1B (0.48) | HSD17B10 | |
| SCHEMBL31705275 | 0.76 | CKS1B (0.48) | HSD17B10 | |
| SCHEMBL31704852 | 0.75 | GPR119 (0.53) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137984-A1 | INHIBITORS OF KIF18A AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024137984-A1 | INHIBITORS OF KIF18A AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |