Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.41 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27569712 | 0.88 | HPGDS (0.52) | ALDH1A1VCAM1ABCG2RAD51CYP3A4 | |
| SCHEMBL30155014 | 0.88 | ALDH1A1 (0.58) | ALDH1A1VCAM1ABCG2RAD51MEN1 | |
| SCHEMBL31067280 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL7473834 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL16289375 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL4816985 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL14906745 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL10762975 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL28811214 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP3A4NAMPTXDHPOLB | |
| SCHEMBL2964677 | 0.75 | TTR (0.56) | ALDH1A1VCAM1CYP3A4NAMPTXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922390-B | COT modulators and methods of use thereof | 吉利德科学公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-104203242-B | Substituted quinolines as Bruton's tyrosine kinase inhibitors | 杭州德润玉成生物科技有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-100432055-C | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2008-11-12 | — | — | CN | disclosed |
| CN-101223143-A | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |
| CN-1262541-C | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2006-07-05 | — | — | CN | disclosed |
| CN-1704404-A | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2005-12-07 | — | — | CN | disclosed |
| CN-1703204-A | Stabilized pharmaceutical composition containing basic excipients | WYETH CORP (US) | 2005-11-30 | — | — | CN | disclosed |
| CN-1190197-C | Application of cyanoquinoline in preparing medicine for treating or inhibiting colonic polyp | HEWLETT HOLDINGS CORP (US) | 2005-02-23 | — | — | CN | disclosed |
| CN-1165532-C | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | ���Ͽع�����˾ | 2004-09-08 | — | — | CN | disclosed |
| CN-1144786-C | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | 谷 | 2004-04-07 | — | — | CN | disclosed |
| CN-1121391-C | Substituted 3-cyano quinolines | AMERICAN CYANAMID CO (US) | 2003-09-17 | — | — | CN | disclosed |
| CN-1437584-A | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2003-08-20 | — | — | CN | disclosed |
| CN-1429126-A | Use of cyanoquinolines for treating or inhibiting colonic polyps | AMERICAN CYANAMID CO (US) | 2003-07-09 | — | — | CN | disclosed |
| CN-1320121-A | Substituted 3-cyanoquinolines as protein tyrosine kinase inhibitors | AMERICAN CYANAMID CO (US) | 2001-10-31 | — | — | CN | disclosed |
| CN-1320118-A | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | AMERICAN CYANAMID CO (US) | 2001-10-31 | — | — | CN | disclosed |
| CN-1259125-A | Substituted 3-cyanoquinolines | AMERICAN CYANAMID CO (US) | 2000-07-05 | — | — | CN | disclosed |