Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705739 | 0.91 | HTR6 (0.61) | POLBHDAC6HDAC10HTR6ALDH1A1 | |
| SCHEMBL4595500 | 0.83 | POLB (0.64) | POLBHDAC6HDAC10HTR6ALDH1A1 | |
| SCHEMBL2006750 | 0.80 | PLA2G4A (0.68) | POLBHDAC6HDAC10HTR6ALDH1A1 | |
| SCHEMBL27846396 | 0.79 | POLB (0.62) | POLBHDAC6HDAC10HTR6ALDH1A1 | |
| SCHEMBL15700115 | 0.78 | POLB (0.83) | POLBHDAC6HDAC10HTR6ALDH1A1 | |
| SCHEMBL1859925 | 0.78 | POLB (0.64) | POLBHDAC6HDAC10HTR6CHRNB2 | |
| SCHEMBL5329307 | 0.77 | POLB (0.72) | POLBHDAC6HDAC10HTR6ALDH1A1 | |
| SCHEMBL12706043 | 0.77 | CHRNB2 (0.68) | POLBHDAC6HTR6ALDH1A1CHRNB2 | |
| SCHEMBL2051630 | 0.76 | ALDH1A1 (0.80) | POLBHDAC6HTR6ALDH1A1CHRNB2 | |
| SCHEMBL27927349 | 0.76 | RAD52 (0.42) | HDAC6HDAC10HTR6ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1141627-A | Indole derivatives for the treatment of estrogen-related tumors and diseases | MERRELL DOW PHARMA (US) | 1997-01-29 | — | — | CN | disclosed |