Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Turofexorate Isopropyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 known ✓ | Q96RI1 | 20/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Turofexorate Isopropyl SCHEMBL29382704 | 1.00 | NR1H4 (1.00) | NR1H4ESR1NR3C1PGRNR3C2 | |
| Turofexorate Isopropyl SCHEMBL29823687 | 1.00 | NR1H4 (1.00) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4528753 | 0.93 | NR1H4 (0.87) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4522612 | 0.93 | NR1H4 (0.87) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4526791 | 0.92 | NR1H4 (0.86) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4521569 | 0.92 | NR1H4 (0.86) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4514020 | 0.92 | NR1H4 (0.84) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL3734487 | 0.91 | NR1H4 (1.00) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4521794 | 0.91 | NR1H4 (0.83) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4535312 | 0.91 | NR1H4 (0.83) | NR1H4ESR1NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133992-B2 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | EXELIXIS, INC. (US) | 2012-03-13 | — | — | US | claimed |
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | claimed |
| US-20090326218-A1 | Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents | EXELIXIS, INC. (US) | 2009-12-31 | — | — | US | claimed |
| US-20090215748-A1 | FXR agonists for treating vitamin D associated diseases | WYETH (US) | 2009-08-27 | — | — | US | claimed |
| US-20090163474-A1 | FXR Agonists for the Treatment of Nonalcoholic Fatty Liver and Cholesterol Gallstone Diseases | WYETH (US) | 2009-06-25 | — | — | US | claimed |
| US-7485634-B2 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | EXELIXIS, INC. (US) | 2009-02-03 | — | — | US | claimed |
| US-20080299118-A1 | FXR Agonists for the Treatment of Malignancies | WYETH (US) | 2008-12-04 | — | — | US | claimed |
| US-20080300235-A1 | FXR Agonists for Reducing LOX-1 Expression | WYETH (US) | 2008-12-04 | — | — | US | claimed |
| JP-2007513168-A | — | — | 2007-05-24 | — | — | JP | claimed |
| EP-1692136-A2 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-Ceptor Therapeutics, Inc. (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005056554-A2 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2005-06-23 | — | — | WO | claimed |
| US-20050054634-A1 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | AKARNA THERAPEUTICS, LTD. (GB) | 2005-03-10 | — | — | US | claimed |
| US-20040023947-A1 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | X-CEPTOR THERAPEUTICS INC. | 2004-02-05 | — | — | US | claimed |
| EP-4090327-B1 | USE OF FXR AGONISTS FOR TREATING AN INFECTION BY HEPATITIS D VIRUS | INST NAT SANTE RECH MED (FR) | 2025-03-05 | — | — | EP | disclosed |
| US-20240216364-A1 | STRONG POTENTIATION OF TLR3 AGONISTS EFFECTS USING FXR AGONISTS AS A COMBINED TREATMENT | ENYO PHARMA (FR) | 2024-07-04 | — | — | US | disclosed |
| CN-118223147-A | Preparation method of antistatic graphene modified nylon special-shaped fiber | 江苏江山红化纤有限责任公司 | 2024-06-21 | — | — | CN | disclosed |
| EP-1692136-A2 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-Ceptor Therapeutics, Inc. (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056554-A2 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| US-20050054634-A1 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | AKARNA THERAPEUTICS, LTD. (GB) | 2005-03-10 | — | — | US | disclosed |
| US-20040023947-A1 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | X-CEPTOR THERAPEUTICS INC. | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023947-A1 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | HTR5A, MTNR1A, PTGDR | NR1H4 268/4885ESR1 394/4885NR3C1 231/4885 |
| US-20240216364-A1 | STRONG POTENTIATION OF TLR3 AGONISTS EFFECTS USING FXR AGONISTS AS A COMBINED TREATMENT | TLR3, NR1H4, TLR9 | NR1H4 2/4885ESR1 2032/4885NR3C1 204/4885 |
| US-20090326218-A1 | Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents | HTR5A, MTNR1A, PTGDR | NR1H4 268/4885ESR1 394/4885NR3C1 231/4885 |
| US-20050054634-A1 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | GPR119, IRS1, INSR | NR1H4 75/4885ESR1 755/4885NR3C1 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.