Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.66 |
| ▸ | RXRA | P19793 | 1/20 | 0.64 |
| ▸ | RXRB | P28702 | 1/20 | 0.64 |
| ▸ | RXRG | P48443 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.61 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | YAP1 | P46937 | 1/20 | 0.60 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10050566 | 0.88 | EGFR (0.64) | MEN1KMT2ARNF114RXRARXRB | |
| SCHEMBL14665712 | 0.86 | RNF114 (0.60) | MEN1KMT2ARNF114L3MBTL1GRIN2D | |
| SCHEMBL27465865 | 0.86 | RNF114 (0.88) | MEN1KMT2ARNF114L3MBTL1MAPT | |
| SCHEMBL246222 | 0.85 | ALDH1A1 (0.65) | RNF114L3MBTL1GRIN2DGRIN2CACHE | |
| SCHEMBL10074852 | 0.83 | POLB (0.68) | MEN1KMT2ARNF114L3MBTL1 | |
| SCHEMBL14133876 | 0.83 | KDM4E (0.80) | MEN1KMT2ARXRARXRBRXRG | |
| SCHEMBL31574504 | 0.82 | MEN1 (0.59) | MEN1KMT2ARNF114L3MBTL1GRIN2D | |
| SCHEMBL3319335 | 0.82 | KDM4E (0.70) | MEN1KMT2ARXRARXRBRXRG | |
| SCHEMBL12857571 | 0.81 | YAP1 (0.74) | RXRARXRBRXRGL3MBTL1YAP1 | |
| SCHEMBL14665638 | 0.80 | MAPT (0.91) | RXRARXRBRXRGMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9091678-B2 | Method for identifying compounds useful for treating and/or preventing disease-associated bone loss | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |